A new bill will centralize the approval process for multinational trials and mandate the publication of trial results—good or bad.
If new results hold up, enhanced phosphorylation of a ribosomal protein may explain the toxicity of mutations that cause Parkinson's.
A small molecule inhibitor kills all microglia in the brain, but the cells rapidly repopulate from a previously unidentified progenitor cell.
Allegations of scientist misconduct led to the retraction of one high-profile stem cell paper and put two others in doubt.
A new study charges that, contrary to previous studies, seeding the mouse brain with aggregated α-synuclein does not trigger a toxic spread of PD-like inclusions in wild-type mice.
Nucleotide repeat expansions in the C9ORF72 gene occur in amyotrophic lateral sclerosis and frontotemporal dementia. Now researchers find the same repeats in patients with two other neurological disorders.
New research suggests that dendritic tau may participate in synaptic plasticity, and that Aβ disrupts this function.
Tirasemtiv, a drug thought to make muscles more sensitive to signals from motor neurons, failed to improve muscle function in people with amyotrophic lateral sclerosis.
Scientists claim that AV-133, an imaging agent that visualizes dopaminergic neurons, can gauge progression of Parkinson’s disease.
Scientists generate human embryonic stem cell lines from adult donor cells, building on earlier studies that showed this was possible with fetal cells.
Copper Mountain: Can CREB Save Memory? Copper Mountain: Knight Vision—SIRT1 Aids ADAM10, Slays Aβ Copper Mountain Brief: Rat-a-tat—New Model Comes a Knockin’ Copper Mountain: Death and Trophin Receptors—New Insight, New Drugs? Copper Mountain: Fractious ...
Keystone: γ Slowly Relinquishes Its Secrets Keystone: Lipids Grease γ-Secretase Activity Keystone: Loss Versus Gain—Mutations a Drag on γ-Secretase Fiendishly complicated, γ-secretase has proved a formidable foe to the structurally minded scientist. But ...
Zuers—Meeting Mixes Translational News and Debate Zuers—Αlpha, Beta, Sigma: Which Will Yield New AD Drug? Zuers—No Pill or Drip: Scientists Inject Phage Drug Into CSF Zuers—Can Spatial Navigation Guide Clinical Trials? The town of Zuers in the Austrian ...
St. Louis: ApoE Receptors—Hold Sway Over Synaptic Function St. Louis: ApoE—Receptors, Theories and Therapies St. Louis: ApoE—A Clearer View of its Role In AD? The apolipoprotein E gene is the strongest genetic risk factor for late-onset Alzheimer disease. ...
Therapeutic Approaches Target Deubiquitinase, Protein Turnover Paracrine Signal From BACE1-Clipped Neuregulin Rescues Myelin Could Longevity Factor, Epilepsy Med, Treat AD One Day? The small scientific workshop From Science to Therapeutics: The Best Way ...
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