The ADCS–PACC, a new cognitive composite test to be used in the A4 prevention trial, detects subtle deficits in older adults with brain amyloid.
AFFiRiS AG claims that a placebo formulation, not their active Aβ vaccine, slowed the progression of Alzheimer's disease in a Phase 2 study.
Researchers link frontotemporal dementia pathology to DNA damage.
Supplements of resveratrol, a compound found in red grapes and wine, improved memory, metabolism, and brain connectivity in a group of overweight older adults.
Brain-training websites tout their games’ potential to boost cognition, but strong evidence and firm backing by the scientific community have yet to surface.
While scientists remain on the fence over whether computer games benefit cognition, some are finding new uses for gaming data in clinical trial research.
Does amyotrophic lateral sclerosis start at the interface between mitochondria and the endoplasmic reticulum?
Patient-derived macrophages are the latest model of Gaucher’s disease, a lysosomal storage disorder. The cells may help researchers better understand disease phenotypes and test candidate therapies.
Scientists advance a new explanation for how Aβ dampens synaptic plasticity.
Researchers argue for a public-private superfund to advance many Alzheimer’s therapeutics projects in parallel.
Passive immunotherapy shows moderate success in a mouse model of sporadic Parkinson’s disease.
Levodopa may have a slight edge over newer treatments for Parkinson’s disease.
A new interface allows researchers to mix and match data from genome-wide association studies in search of genes involved in sporadic amyotrophic lateral sclerosis.
A novel mutation frays mitochondrial DNA and impedes ATP synthesis in people with an ALS-FTD-like syndrome.
Several thousand people have used preimplantation genetic diagnosis to avoid passing on pathogenic mutations to their babies, but many families with a history of Alzheimer’s or related diseases remain unaware of this option.
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