New targets and compounds with which to hit them took up much space on the program...
In mouse models, removing this growth factor only from immune cells worsened pathology and memory.
Brain extracts from AD patients, but not their cerebrospinal fluid, contain exceedingly potent Aβ seeds that survive formaldehyde treatment. The findings further implicate Aβ in prion-like pathology.
Getting a close-up view of nicastrin, scientists find more evidence that this γ-secretase subunit snags substrates for presenilin.
Researchers pumped gel and detergents through rodents to make their entire bodies clear. The new technique will allow scientists to image cells throughout the body.
The Aβ-binding alcohol dehydrogenase (ABAD) forms a complex with Aβ in mitochondria, promoting leakage of free radicals, mitochondrial dysfunction, and cell death...
Two studies claim that α-synuclein multimers have a physiological role as wranglers of synaptic vesicles. They come to different conclusions on the finer points, but could they fit into one grand model?
Neural circuits in the hippocampus defy current views about its structure and function.
Allegations of falsified data embroil Japanese ADNI; project leaders respond that data corrections followed quality-control procedures.
Neurons derived from an octogenarian donor thrived in rat spinal cord lesions, extending thousands of axons along the length of the cord, even into the cortex.
Starved for a protein that regulates lipids, neurons suffer and Aβ production soars, according to a new study.
A new assay detects tau and α-synuclein seeds in human brain samples. Could it become a diagnostic?
A study claims that two genetic variants combined may hasten cognitive decline in people who have Aβ deposits in the brain.
MGH meeting traces arc of scientific discoveries from 1980s to today’s cutting edge.
The pharma giant puts up funding to help develop AstraZeneca’s inhibitor, the second such compound to enter Phase 2 testing.
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