Motor and cortical neurons are particularly vulnerable to FUSopathy. A new paper suggests they fail because they depend strongly on FUS to regulate transcription.
Alzheimer’s and prion disease may be linked through an α-secretase.
Researchers identified a genetic variant in the microglial gene CD33 that protects against Alzheimer’s.
Two studies examine factors that heighten the risk for dementia in type 2 diabetes patients. Both highlight depression as a dangerous comorbidity.
Is transfer of tau from one neuron to the next a normal activity, hijacked by pathogenic protein in the case of tauopathies?
Expansions in ataxin-2 can lead to either ALS or spinocerebellar ataxia—even in the same family, according to a new pedigree from New York.
Functional genomics and mouse analyses blame waning levels of histone-binding protein for memory loss in aging.
A stem cell-derived structure mimics crucial features of human brain development and could aid studies in schizophrenia, autism, maybe neurodegeneration.
In sporadic and familial Parkinson's, faulty parkin may damage dopamine neurons by letting a deadly protein linger.
Researchers say that analyzing long stretches of homozygosity in people of Caribbean Hispanic descent represents an approach to finding rare, recessive Alzheimer’s mutations.
Preliminary data from Parkinson’s Progression Markers Initiative suggests that cerebrospinal fluid biomarkers distinguish the most rapidly progressing form of Parkinson’s.
Researchers nabbed rare variants in Alzheimer’s genes by sequencing DNA from people with very high or very low levels of cerebrospinal fluid biomarkers.
Fueling (or rekindling) controversy over anti-aging benefits of sirtuins, researchers report that Sirt1 lengthens lifespan in mice.
As heat shock protein and co-chaperone team up to shield tau from degradation, they create toxic oligomers.
Amyloid fibrils seeded by Alzheimer’s brain extracts indicate that Aβ forms specific strains in different individuals.
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