Magnetic resonance spectroscopy bolsters hypothesis that ALS results from too much glutamate and too little GABA
Growing evidence suggests that innate immune cells prevent or slow Alzheimer's disease by chewing up Aβ and promoting its clearance.
Courts in Europe revoked a patent that laid claim to all passive immunotherapy for Alzheimer’s disease, clearing the way for others to freely pursue this strategy...
Researchers identify the Aβ-binding scavenger receptor CD36 as a key regulator of macrophage inflammasome responses...
Scientists have discovered yet another function for β-secretase (BACE1), the enzyme that kick-starts amyloidogenic processing of the amyloid-β precursor protein...
Mouse studies point to a new pathway that mediates motor neuron disease caused by mutations in superoxide dismutase 1.
Struggles to develop therapeutic antibodies for prion disease teach scientists how prion protein may kill neurons.
A DNA-based Aβ vaccine appears safe and produces a strong immune response in monkeys, suggesting it could work in people.
Neurons clear misfolded proteins at different speeds. Is this why some brain regions are more vulnerable to neurodegeneration than others?
Knocking down tau expression in adult mice diminishes induced seizures.
Mass spectrometry data show how γ-secretase modulators skew APP processing toward Aβ40 rather than Aβ42, without upsetting cleavage of other substrates.
Tau ligands for PET scans were among the hot topics at the Alzheimer’s Association International Conference in Boston.
Motor and cortical neurons are particularly vulnerable to FUSopathy. A new paper suggests they fail because they depend strongly on FUS to regulate transcription.
Researchers identified a genetic variant in the microglial gene CD33 that protects against Alzheimer’s.
Alzheimer’s and prion disease may be linked through an α-secretase.
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