The route to early dementia starts in adolescence, with low cognitive function and alcohol intoxication as major predictors.
Expansions in ataxin-2 can lead to either ALS or spinocerebellar ataxia—even in the same family, according to a new pedigree from New York.
Is transfer of tau from one neuron to the next a normal activity, hijacked by pathogenic protein in the case of tauopathies?
A stem cell-derived structure mimics crucial features of human brain development and could aid studies in schizophrenia, autism, maybe neurodegeneration.
Functional genomics and mouse analyses blame waning levels of histone-binding protein for memory loss in aging.
Researchers say that analyzing long stretches of homozygosity in people of Caribbean Hispanic descent represents an approach to finding rare, recessive Alzheimer’s mutations.
In sporadic and familial Parkinson's, faulty parkin may damage dopamine neurons by letting a deadly protein linger.
Researchers nabbed rare variants in Alzheimer’s genes by sequencing DNA from people with very high or very low levels of cerebrospinal fluid biomarkers.
Fueling (or rekindling) controversy over anti-aging benefits of sirtuins, researchers report that Sirt1 lengthens lifespan in mice.
Without the protein beclin 1, rapacious microglia choke on amyloid β.
As heat shock protein and co-chaperone team up to shield tau from degradation, they create toxic oligomers.
New research connects extracellular Aβ to intracellular kinases that mediate its toxicity.
A new study supports the idea that non-motor symptoms of Parkinson's disease may aid earlier diagnosis.
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