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New Tricks in Measuring Fibril Formation

The formation of amyloid plaques starts with soluble amyloid-β monomers, which coalesce to form small oligomers, protofibrils, fibrils, and finally the amyloid plaques that pack the intraneural spaces in the brains of Alzheimer's patients...

SUMO-Wrestling with APP?

In the January 7 PNAS, researchers from the biopharmaceutical company Scios Inc. reported that sumoylation, the covalent modification of lysine residues by small ubiquitin-like modifier (SUMO) proteins, has a dramatic impact on amyloid β production...

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