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Pinning Prions to the Cytosol

Prions, those self-replicating proteins responsible for scrapie, mad cow disease, and some human neurologic diseases, have been notoriously difficult to pin down in the cell. Now, an international collaboration reports perhaps the most detailed localization study to date...

Measuring Protein Folding One Molecule at a Time

Scientists have long puzzled over the following conundrum: If the activity of a protein solution drops by half, have half the molecules completely lost activity, or have all the proteins lost half their activity? The answer, most likely, is that...

Oligomers in AD: Too Much of a Bad Thing?

Neuritic plaques are classic, obvious markers of Alzheimer’s disease, but it is a puzzle why their density is a poor predictor of disease symptoms. Recently, scientists have come to suspect that soluble oligomeric, not fibrillary, β, may be the culprit in synaptic degeneration in AD...

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