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Stockholm: Degradation on the Rise

Malcolm Leissring reports on the latest data, presented at the 8th International Conference on Alzheimer’s Disease and Related Disorders in Stockholm, on the role of insulin-degrading enzyme and neprilysin in degrading Aβ peptide in vivo....

Are Random Mutations Not So Random?

David Altshuler and colleagues at the Whitehead Institute report that only a small fraction of SNPs arise by random mutation and that most SNPs are inherited. These findings should have a profound effect on those researchers hunting for genetic clues to disease....

Mouse Genome Mapped

Members of the International Mouse Genome Consortium reported this week that they have succeeded in making a physical map of this rodent’s genome using, ironically, the sequence of the human genome as a template....

More on Biomarkers That Signal Longevity

Humans who live longer display the same biomarkers found in laboratory animals who have restricted caloric intake. However, because these human subjects weren't actively restricting their caloric intake, there may be other ways to increase life span in humans...

Stockholm: There Is No Spatial Paradox!

More news updates from the 8th International Conference on Alzheimer’s Disease and Related Disorders in Stockholm: In a wide-ranging and eloquent presentation, Christian Haass provided several experimental proofs that a small amount of presenilin is detected at the plasma membrane...

Go FISH

Researchers at the Albert Einstein College of Medicine in New York demonstrate the use of fluorescence in situ hybridization, or FISH, to measure multiple transcription events in vitro...

Stockholm: Liver Found to Degrade Aβ

The Aβ peptide that circulates in the periphery is degraded not primarily by the kidney, but in the liver, scientists report at the 8th International Conference on Alzheimer’s Disease and Related Disorders in Stockholm.

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