In a series of eight reviews, titled "Focus on Neurotechniques," researchers describe how approaches such as optogenetics and stem cells are revolutionizing neuroscience.
Eating fewer saturated fats and simple sugars reduces harmful forms of Aβ in the cerebrospinal fluid, scientists report.
The experimental drug NitroMemantine protects synapses from Aβ oligomer toxicity in mice by blocking extrasynaptic NMDA receptors.
Brain imaging distinguishes ALS patients with C9ORF72 expansions from those with other forms of the disease.
An ultra-high-resolution 3D map of the human brain promises to help scientists studying neuroanatomy, neurosurgery, neurodegenerative disease, and more.
Before cognition falters, Alzheimer’s disease wreaks havoc on synapses, the brain’s subcellular communication hubs.
Despite ample evidence implicating Aβ in Alzheimer’s pathology, scientists still struggle to understand how the peptide harms the brain.
A report on global disease burden found that the number of deaths in China due to Alzheimer’s disease and other dementias doubled between 1990 and 2010.
Researchers have long assumed that people with familial Alzheimer’s disease make too much Aβ42 in the brain, but they lacked proof.
Eli Lilly and Company announced yesterday that they have terminated the Phase 2 trial of their BACE inhibitor LY2886721 due to liver abnormalities.
It’s a scenario familiar to many clinicians: A patient diagnosed with mild cognitive impairment asks if he or she will eventually develop Alzheimer’s disease.
As potential AD drugs continue to post disappointing Phase 2/3 results, many in the field are considering upping the artillery by testing experimental drugs in combination.
After more than a decade in the works, the long-awaited fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) arrived last month to little fanfare.
Though iron gets a bad rap for accumulating in the brains of older people and individuals with neurodegenerative disease, could an abundance of this metal in the blood bode well?
Tiny blood vessels in the mouse brain crisscross the cortex, passing from one neural column to the next, like multiple streets between interconnecting city blocks...