A third trial continues in the United States
The fragment occurs naturally and rises after BACE inhibition, adding another layer of complexity to inhibitor therapy.
In two trials, moderate exercise or supplements of omega-3 fatty acids and antioxidants failed to alter the course of cognitive decline in older adults.
Three studies report that the C9ORF72 expansion prevents RNAs and proteins from shuttling properly between nucleus and cytosol.
A new report paints a stark picture of the coming wave of dementia cases and their staggering cost if prevention or treatment fails to stem the tide.
Scanning for amyloid plaques in the brain may help clinicians diagnose and manage patients with a questionable diagnosis of Alzheimer’s.
The largest trial yet of ApoE4 carriers is pioneering new protocols with increasing use of technology to reach thousands of potential participants and disclose risk information.
Prevention trials are testing new protocols for telling potential participants about their heightened risk for dementia, and exploring the psychological effect of such disclosures.
The intracellular domain of the amyloid precursor protein may alter gene expression to reduce production of Aβ.
The synaptic protein abounds in the cerebrospinal fluid of AD patients and in those in the prodromal phase of the disease.
Researchers have generated the first atomic-level structure of γ-secretase. The new view revealed interactions between amino acid residues and the locations of familial Alzheimer’s disease mutations.
In a clinical trial, people who used the surgically implanted breathing-assist device died nearly a year sooner than those who used only an oxygen mask.
Can proteins in the cerebrospinal fluid help tell movement disorders apart and predict who will develop dementia?
Though BACE1 and γ-secretase appear to orchestrate axonal pathfinding, researchers doubt inhibitors or modulators of these proteases would cause side effects in people treated for AD.
Research uncovers subtle links between early development problems and some forms of dementia.