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Learn the Skinny on iPS Cells in Neurodegenerative Disease

Are you curious about trying iPS cell lines to model the disease you care about? Intrigued but nebulous on where the field is at? Ready to grow an iPS line but not sure where to turn? Read Madolyn Rogers's four-part series to learn all about who does ...

New Genetics—From Sequence to Knowledge

When the first human genome sequence was finished in 2003, it quickly became clear that its seemingly unending stream of letters was not enough to comprehend what makes people tick. All the moving parts that bring the DNA code to life needed to be ...

Cortical Hubs to Rich Clubs—Linking Brain Connectivity to Function

If you find it hard to keep up with Facebook, LinkedIn, and other social networks, spare a thought for the brain. With 100 to 500 trillion synaptic connections, the human brain dwarfs all of them. How do those connections work to formulate thought, recall ...

Deep-Brain Stimulation: Surgical Relief for Parkinson's and Beyond

In this series, ARF takes stock of deep-brain stimulation after more than a decade of life-altering procedures,  In deep brain stimulation, surgeons implant wires into the brain and hook them up to a pacemaker-like stimulator implanted in the chest, which ...

The Alzheimer's Disease Neuroimaging Initiative

The Alzheimer's Disease Neuroimaging Initiative is the most expensive AD study the NIH has ever funded. Expectations are that it will speak with the authoritative voice of a 58-center, three-year observation of 819 research participants above a ...

Metabolomics Comes of Age

Move over, genome, transcriptome, proteome. The latest ome aims to map every metabolite linked to human health and disease. Metabolomics, although still a nascent field, offers hope for biomarkers and treatments in neurodegenerative disease. The field& ...

To Sleep, Perchance to Clean…the Brain, Make Memories

Researchers have tied sleep to clearance of waste products such as excess Aβ. New research suggests this clearance may be driven by a change in the extracellular ion composition, which swells the interstitial fluid. Other work finds an essential role for ...

Preimplantation Genetic Diagnosis: A Family Choice

For families with autosomal-dominant neurological conditions, the fear of passing on the disease to their children looms large. Now, people at this highest genetic risk can ensure that they have healthy children by undergoing in vitro fertilization ...

CRISPR: A New Tool For Gene Editors

CRISPR Gene Editing—Poised to Revolutionize Neuroscience? Neuroscientists Probe CRISPR Transgenics and Treatment Paradigms ...

A Contentious Hypothesis About Where and How PD Starts

A contentious hypothesis about where and how Parkinson’s disease starts off is gaining ground as new studies provide clues in its support. Neuroanatomists Heiko Braak and Kelly Del Tredici, both at the University of Ulm in Germany, have described the ...

Brain Training—Plain Gaming, or a New Vein for Preclinical Research?

If you listen to National Public Radio, watch TV, or surf the Web, chances are you have come across commercials enticing you to “improve your memory” and “unlock your inner genius” with “brain training developed by neuroscientists.”  In search of solid ...

Medical Foods for Alzheimer's: Palatable Therapy or Snake Oil?

In the absence of truly effective treatments, and in the presence of a rapidly growing, dementia-prone population of elders, it's perhaps no surprise that people are increasingly open to products claiming even the slightest hint of promise, however ...

Alzheimer's Association International Conference 2013

Cerebrospinal Fluid Tau Climbs in Aβ Mouse Models Coverage Denial For Amyloid Scans Riles Alzheimer’s Community Pooled GWAS Reveals New Alzheimer’s Genes and Pathways Are Subtle Memory Concerns a Sign of Future Dementia? Clinical Trials Roundup: Four Hits ...

International Conference on Alzheimer's Disease 2006

Madrid: ICAD Conference Draws to a Close Madrid: BACE Found to Have Big Job in Wrapping Motoneurons Madrid: Why Do People Drop Out of Trials? Madrid: Stressed Brain—SNP Carriers Can Have Cake and Eat It Madrid: BACE News Roundup, Part 1 Madrid: BACE News ...

International Conference on Alzheimer's Disease 2004

Philadelphia: All Eyes on PIB Imaging—Is It Coming Along? Philadelphia: All Is Not Well with the Statin Story Philadelphia: Can a Shrinking Brain Be Good for You? Philadelphia: Dementia Types Just Won’t Fit into Little Boxes Philadelphia: Diagnosis Light ...

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