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Michael J. Fox Foundation Launches Big PD Biomarker Study

A $40 million multicenter biomarker study for Parkinson disease progression is off and running, with enrollment underway at 10 of 18 sites in the U.S. and Europe. In design and operation, the  Parkinson's Progression Markers Initiative  (PPMI) ...

CRISPR: A New Tool For Gene Editors

CRISPR Gene Editing—Poised to Revolutionize Neuroscience? Neuroscientists Probe CRISPR Transgenics and Treatment Paradigms ...

Modern Microscopy

Modern Microscopy Skims Surface of Living Minds and Spines Modern Microscopy Plumbs the Depths of Brain Tissue ...

Metabolomics Comes of Age

Move over, genome, transcriptome, proteome. The latest ome aims to map every metabolite linked to human health and disease. Metabolomics, although still a nascent field, offers hope for biomarkers and treatments in neurodegenerative disease. The field& ...

A Contentious Hypothesis About Where and How PD Starts

A contentious hypothesis about where and how Parkinson’s disease starts off is gaining ground as new studies provide clues in its support. Neuroanatomists Heiko Braak and Kelly Del Tredici, both at the University of Ulm in Germany, have described the ...

Will Technology Revolutionize Dementia Diagnosis and Care?

As populations age worldwide and the number of people with dementia is set to soar over the next few decades, a crisis in eldercare looms. At the same time, the use of personal technology—smartphones, tablets, wearable monitors—is exploding. Can ...

Preimplantation Genetic Diagnosis: A Family Choice

For families with autosomal-dominant neurological conditions, the fear of passing on the disease to their children looms large. Now, people at this highest genetic risk can ensure that they have healthy children by undergoing in vitro fertilization ...

Deep-Brain Stimulation: Surgical Relief for Parkinson's and Beyond

In this series, ARF takes stock of deep-brain stimulation after more than a decade of life-altering procedures,  In deep brain stimulation, surgeons implant wires into the brain and hook them up to a pacemaker-like stimulator implanted in the chest, which ...

Stress and Trauma: New Frontier Calling AD Researchers

With the nation at war for eight continuous years, and awareness of the dangers of sports concussions on the rise, a new priority—and opportunity—are taking shape for neurodegenerative disease researchers. In a time of austere budgets, the Department of ...

Society for Neuroscience Annual Meeting 2013

Researchers Revel in C9ORF72 Advances at RNA Symposium Profilin-1 Links Cytoskeleton and RNA Aggregation in ALS The Four Stages of TDP-43 Proteinopathy Blocking a MicroRNA Slows Motor Neuron Disease in Mice Glial Cells Refine Neural Circuits Innate Immune ...

Patient Engagement in Clinical Trials

A Conference Devoted to Better Engaging Clinical Trial Volunteers Turning to the Internet for Alzheimer’s Trial Volunteers Patient Engagement in Clinical Trials ...

G8 Dementia Summit

European Project Mixes Adaptive Design with Trial-Ready Cohort G8 Vows to Improve Care, Cure Dementia G8 Dementia Summit ...

Keystone Symposium: Alzheimer's Disease

Keystone: γ Slowly Relinquishes Its Secrets Keystone: Lipids Grease γ-Secretase Activity Keystone: Loss Versus Gain—Mutations a Drag on γ-Secretase Fiendishly complicated, γ-secretase has proved a formidable foe to the structurally minded scientist. But ...

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