Neurons derived from an octogenarian donor thrived in rat spinal cord lesions, extending thousands of axons along the length of the cord, even into the cortex.
Not the RNA aggregates, but the repeat dipeptides made from expansions in the C9ORF72 gene are responsible for neurodegeneration, a study claims.
Researchers continue to screen blood for factors that signal neurodegenerative disease.
In a large observational study, high blood pressure in midlife correlated with faster cognitive decline over the next two decades.
Connections across neural networks break down as cognition declines in people with different forms of AD, suggesting the wiring problems may be a hallmark of disease progression.
Compounds that bind RNA temper toxicity related to ALS and FTD.
According to new research, as both mice and humans grow older, immune signals change at the interface between blood and cerebrospinal fluid.
Researchers predict that a new BACE1 mouse recapitulates the early stages of sporadic Alzheimer’s, and can serve as a testing ground for BACE1 inhibitors.
An active immunotherapy is coming to the fore as researchers continue to try novel therapies.
Does a tau-based early diagnosis look more likely?
In gritty and sometimes harrowing detail, activist Meryl Comer describes the reality of caring for a loved one with Alzheimer’s disease.
Blocking the microglial receptor for pro-inflammatory prostaglandin D2 protects motor neurons from glial toxicity in ALS cell and mouse models.