A new project to identify factors that allow some carriers of pathogenic mutations to escape their genetic destinies could be applicable to neurodegenerative diseases.
Engaging in cognitive activities throughout life staves off decline. It also delays Aβ accumulation, two studies report.
Belying some earlier reports, a new study finds that grafted dopamine cells continue to innervate neural networks years after transplantation.
Researchers are ramping up efforts to target tau for Alzheimer’s and other tauopathies.
Head injury increases one’s chances of future dementia by 60 percent, according to a study in veterans.
Aβ aggregates can assume a variety of structures that appear to have unique properties.
Could exosomes—tiny parcels extruded from cells—make for a blood-based Alzheimer’s marker?
Researchers pumped gel and detergents through rodents to make their entire bodies clear. The new technique will allow scientists to image cells throughout the body.
Some macrophages use their dying breath to emit a distress signal that could spell trouble for their neighbors.
Heart-healthy foods containing omega-3 fatty acids, like salmon, slash risk of developing ALS by one-third.
Allosteric γ-secretase modulator binds an extracellular pocket on presenilin, changing the active site.
The largest meta-analysis done to date confirms dramatic variability in age at onset of autosomal-dominant Alzheimer's disease overall, but finds mutation type and parental age at onset to be strong predictive modulators.
Could astrocyte neurotransmission explain memory loss in Alzheimer's disease?
A candidate reference method for measuring Aβ42 in cerebrospinal fluid brings researchers closer to standardization.
In award-winning documentary, son traces his mother’s progression into Alzheimer’s disease.