Could astrocyte neurotransmission explain memory loss in Alzheimer's disease?
Aβ aggregates can assume a variety of structures that appear to have unique properties.
Allosteric γ-secretase modulator binds an extracellular pocket on presenilin, changing the active site.
Blocking calcium-dependent protease normalizes lifespan in mouse tauopathy model.
Heart-healthy foods containing omega-3 fatty acids, like salmon, slash risk of developing ALS by one-third.
Researchers are looking to the eye for a cheap, easy way to detect Alzheimer’s pathology in the brain.
Could exosomes—tiny parcels extruded from cells—make for a blood-based Alzheimer’s marker?
Repeat peptides made by the mutant C9ORF72 gene in ALS and FTD enter the nucleolus and obstruct RNA biogenesis.
Researchers are ramping up efforts to target tau for Alzheimer’s and other tauopathies.
The first large-scale surveys of DNA methylation in Alzheimer’s brains turned up numerous altered regions that may point to new genes involved in pathology.
Perfectly healthy mitochondria can sicken neurons simply by being in the wrong place.
Researchers pumped gel and detergents through rodents to make their entire bodies clear. The new technique will allow scientists to image cells throughout the body.
While mice sleep, neurons sprout synapses to solidify fresh skills, according to a new study. The brain also keeps amyloid-β levels low while we snooze.
A candidate reference method for measuring Aβ42 in cerebrospinal fluid brings researchers closer to standardization.
Playing nursemaid, TGF-β helps new neurons in the brain survive, develop, and migrate.