New genetic methods make it possible to measure variations in DNA from one brain cell to the next, and to investigate whether these mosaic mutations contribute to disease.
Blocking a family of proteins called cytohesins helped clear toxic SOD1. Scientists speculate the inhibition just might do the same for other proteins linked to neurodegeneration.
A protein that accumulates in the blood of old mice impairs memory and neurogenesis.
A behavioral variant of Alzheimer’s disease is not accompanied by shrinking of the frontal cortex. Rather, these patients have similar patterns of atrophy as those with typical AD.
Methylation of cytosines that do not precede guanine bases in DNA prominently occurs in the brain, but not the rest of the body. This epigenetic mark may play a role in Rett syndrome.
In children as young as 9 who carry a presenilin 1 mutation, researchers detect subtle functional and structural brain changes.
By recording from individual human brain cells, researchers find that single neurons can instantly encode associations, showing how rapidly they form memories.
A Phase 2b trial finds that the monoamine oxidase B inhibitor sembragiline missed its primary endpoint.
The scale of cortical folding in mammals—from rodents to humans—is dictated by a simple relationship between surface area and thickness.
The Center for Open Science published eight guidelines for journals to boost transparency and reproducibility in research. Will journals implement them?
One, NF-κB, was thought to be protective but seems to have a detrimental role in ALS.
Live imaging in mice finds that smooth muscle cells on arterioles exclusively control cerebral blood flow.
Worm study suggests that tipping the balance between progranulin and its granulin fragments might promote frontotemporal dementia.
Better known for lowering cholesterol, statins appear to spur the production of neurotrophins in the brain.
In mice harboring both pathogenic α-synuclein and Aβ, the former puts the brakes on plaque formation by the latter. The model could offer insight into what happens in people with mixed pathology.
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