In induced cells from people with a C9ORF72 expansion, the number of mutant transcripts matched the number of RNA foci per cell.
The vascular cells, which die off in Alzheimer’s disease, may be crucial for regulating blood supply to the brain.
The acute state of confusion not only accelerates memory loss on its own, but also worsens decline caused by other pathologies, including Alzheimer’s disease.
A gene pegged at driving up AD risk may work by a different mechanism than originally published.
Solanezumab: Did Aβ ‘Reflux’ From Blood Confound Target Engagement in CSF? After Solanezumab: Where Should Alzheimer’s Research Go? At an expert meeting convened by Alzheimer’s Research UK, scientists from Eli Lilly shared Aβ biomarker data from the ...
Branch out, scientists at Alzheimer’s Research UK conference say. Go after tau, glial activation, lipids, in a systematic way. Understand how these pathways connect to the amyloid hypothesis.
Convened by ARUK to learn from the antibody’s billion-dollar bust, industry and academic leaders declare insufficient CNS target engagement, say peripheral sink did not work, and brainstorm how to move forward.
Describing the current and future toll of AD, a new PBS documentary advocates for drastic increases in research funding.
Imatinib, previously reported to inhibit γ-secretase, now appears to isolate APP from BACE as well.
Two parallel studies found different answers as to whether calorie-restricted macaques live longer than ones that eat their fill. A joint analysis sets the record straight.
A new mouse study correlates neurofibrillary tangles with navigation difficulties and impaired firing of “grid cells” in the entorhinal cortex.
The protein Zfp106 adheres to hexanucleotide repeats in RNA encoded by C9ORF72, and also binds ALS-associated proteins. It protects mice and flies from motor neuron disease.
Disabling human tau mRNA in mice prevents—even reverses—tau buildup, suggesting a potential treatment for a multitude of human tauopathies.
A study of samples from people as old as 106 finds that with increasing age, the region-specific patterns of gene expression change in glia, but not neurons.
An NIA-sponsored initiative will generate and characterize numerous models carrying late-onset AD genes, advancing the best for preclinical drug testing.
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