Stacked together, amyloid subunits absorb more light than they do as monomers. Are there implications for fibril detection?
A parkinsonism-associated ubiquitin ligase interacts with parkin to promote mitophagy.
Two new papers this month shore up the connection between cell waste disposal and function of neurons...
A new link between two proteins tied to Parkinson’s has implications for the disease and beyond.
Scientists claim to turn differentiated mouse cells into pluripotent ones with a brief dip in an acid bath—no genetic tweaks necessary.
Tau fragments in cerebrospinal fluid might lead to better prognostic and diagnostic tests.
PINK1 mutations cripple mitochondrial energy production, raising new questions about Parkinson’s disease.
An antioxidant thought to boost mitochondrial function came up short in a large multicenter trial for PD treatment.
Exome sequencing identifies a new Alzheimer’s risk gene—phospholipase D3.
A Keystone symposium underscores the role of lysosomal dysfunction and vesicle trafficking in neurodegenerative disease.
Low levels of 10 phospholipids in blood plasma correlated with future cognitive decline in older adults, hinting at diagnostic potential.
A combination of high clusterin and low Aβ42 in cerebrospinal fluid associates with early Alzheimer’s neurodegeneration, hinting at a mechanistic interaction between the proteins.
Eating fewer saturated fats and simple sugars reduces harmful forms of Aβ in the cerebrospinal fluid, scientists report.
Hunting for rare mutations that cause dementia, researchers have spotted, but not yet snagged, some tantalizing candidates.