Phospholipase D3 Variants Double Sporadic AD Risk
Exome sequencing identifies a new Alzheimer’s risk gene—phospholipase D3.
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Blocking BACE—Do Adult Mouse Phenotypes Predict Side Effects?
Researchers at a meeting on BACE shared concerns that blocking the protease in adults might have unexpected consequences.
G8 Vows to Improve Care, Cure Dementia
G8 leaders set 2025 as their goal to find better treatment for Alzheimer's and vowed to coordinate research and care strategies.
G8 Dementia Summit
European Project Mixes Adaptive Design with Trial-Ready Cohort G8 Vows to Improve Care, Cure Dementia G8 Dementia Summit
European Project Mixes Adaptive Design with Trial-Ready Cohort
A European public-private partnership plans to combine faster enrollment with adaptive trials to hasten drug discovery in Alzheimer's.
BACE—Substrates, Functions, Developmental Phenotypes
As new substrates and functions for BACE continue to emerge, scientists worry about adverse effects of blocking the protease.
BACE Proteases in Health and Disease
Cloistered Retreat Takes the Pulse of BACE Research BACE—Substrates, Functions, Developmental Phenotypes Blocking BACE—Do Adult Mouse Phenotypes Predict Side Effects? Meeting Explores Complex Biology of BACE Regulation BACE Proteases in Health and Disease
Cloistered Retreat Takes the Pulse of BACE Research
Once branded as a difficult target, β-secretase has become the crowd favorite. But might pharma have to cool its jets?
FUS RNA Granules Not So Stressed Out?
Thought to be no place for translation, RNA granules that form in “FUSopathies” turn out to host protein synthesis, after all.
Brain Volume, Myelination Different in Infants Carrying ApoE4
Sleeping in an MRI scanner, babies with ApoE4 genotype reveal myelination and structural differences in brain areas affected in people with Alzheimer’s disease.
Alzheimer’s Whole-Genome Data Now Available From the NIH
The NIH releases whole-genome data from the Alzheimer’s Sequencing Project.
Innate Immune Cells Enlisted to Clear Amyloid, Fight Disease
Scientists are tweaking immune pathways to scavenge amyloid and curb symptoms in Alzheimer’s mice.
Glial Cells Refine Neural Circuits
New research reveals fundamental roles for astrocytes and microglia in shaping neural circuits.
Patient Engagement in Clinical Trials
A Conference Devoted to Better Engaging Clinical Trial Volunteers Turning to the Internet for Alzheimer’s Trial Volunteers Patient Engagement in Clinical Trials
Society for Neuroscience Annual Meeting 2013
Researchers Revel in C9ORF72 Advances at RNA Symposium Profilin-1 Links Cytoskeleton and RNA Aggregation in ALS The Four Stages of TDP-43 Proteinopathy Blocking a MicroRNA Slows Motor Neuron Disease in Mice Glial Cells Refine Neural Circuits Innate Immune
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