NO Kidding? Mitochondria Fission Protein Linked to Neurodegeneration
A surplus of nitric oxide (NO) generally spells bad news for neurons, as does mitochondrial dysfunction...
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A surplus of nitric oxide (NO) generally spells bad news for neurons, as does mitochondrial dysfunction...
Without Nurr1, a gene at the root of a rare form of familial Parkinson disease (PD), the brain’s inflammatory response spirals out of control and damages neurons...
Activated microglia are a feature of Alzheimer and other neurodegenerative diseases, but exactly what rouses these immune cells of the brain out of quiescence is unclear...
Researchers want to shift therapeutic approaches for AD toward earlier detection, and ultimately prevention...
Elan and Wyeth announced today that two ongoing Phase 3 clinical trials of bapineuzumab will discontinue the highest planned dose of 2 mg/kg...
Alzheimer’s Disease International (ADI) and the Fondation Médéric Alzheimer have presented the first global award for psychosocial research in Alzheimer’s and dementia...
The weird and wonderful world of microbes may hand the field of Alzheimer disease research a physiological function for Aβ...
Why do only motor neurons fail in ALS when the cause of pathology, such as mutant protein, exists in many different cells?...
Full-length APP has been suggested to be an adaptor protein that links vesicles to the kinesin motors that power microtubule-mediated transport out to axons, but a new study may be cause to revise that model...
Keystone: Death Receptor Ligand—New Role for APP, New Model for AD? Keystone: Partners in Crime—Do Aβ and Prion Protein Pummel Plasticity? Keystone: Longevity, Insulin-like Growth Factor Signaling, and Aβ Toxicity Keystone: Pulse-Chasing AD Biomarkers, Sn
If a keystone was to be found at the recent symposium held 17-22 February at Keystone, Colorado, it may well have been microRNAs (miRNAs)...
MicroRNAs were a common emerging theme at the recent Keystone Symposium, “Neurodegenerative Diseases: New Molecular Mechanisms,” held 17-22 February at Keystone, Colorado...
Transplanted nerve cells with artificially stretched axons may act as “jumper cables” to guide and accelerate axon regeneration across nerve lesions...
Scientists hold out hope that failing neural circuits may be revived with home-grown nerve cells or with functional neurons raised externally from embryonic stem cells...
The protein tau has for years bedeviled dementia researchers...