Trial Troika—Immunotherapy Interrupted, Lipitor Lags, Dimebon Delivers
A flurry of clinical trial news this past week brought mostly disappointment...
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A flurry of clinical trial news this past week brought mostly disappointment...
Scientists in Germany have created a membrane-tethered version of a β-secretase inhibitor...
Increased β-site cleavage enzyme 1 (BACE1) is one plausible risk for sporadic Alzheimer disease, but what causes this increase?...
One of the big surprises at this year’s Human Amyloid Imaging meeting was the finding that a significant proportion of healthy controls are PIB-positive...
HAI Chicago: PIB in Healthy People HAI Chicago: Can PIB Predict Cognitive Decline? HAI Chicago: PIB and Aβ Show Regional Nuances and Sleep-Wake Rhythm HAI Chicago: Not Just PIB—Other PET Tracers in Clinical Pipeline Human Amyloid Imaging 2008
Many studies using Pittsburgh Compound-B (PIB) have found a fair percentage of normal elderly walking around with heads full of amyloid...
Two genetics papers this month add to the mounting evidence that TAR DNA binding protein (TDP-43) is a key player in ALS and not just an innocent bystander...
In the April 16 Journal of Neuroscience, researchers give a vivid account of the microglia/plaque relationship...
Blood levels of the antioxidant molecule urate are associated with the risk of progression in patients with Parkinson disease, according to a new study...
A company recently announced that it will start marketing a blood test for Alzheimer disease within the year...
Aβ oligomers made in test tubes or found in conditioned cell-culture medium can put a damper on synaptic plasticity...
The connection between synaptic activity and Aβ production in vivo runs through the endocytic pathway...
At the Keystone conference, researchers presented new data to argue that pyroglutamate (pGlu) derivatives of Aβ may be critically important in the underlying pathology of AD...
For the brave patients who elected to have foreign fetal neurons implanted in their brain as an experimental treatment for Parkinson disease (PD), there must have been many agonizing thoughts...
Perhaps no topic is hotter in Alzheimer disease molecular research today than the synaptic effects of amyloid-β (Aβ) oligomers...