The AICD Test? Transgenic Mice Show Neurodegeneration
The carving up of the APP by the successive action of β- and γ-secretases liberates Aβ, but also yields a small intracellular fragment, AICD...
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Medical Foods for Alzheimer's: Palatable Therapy or Snake Oil?
In the absence of truly effective treatments, and in the presence of a rapidly growing, dementia-prone population of elders, it's perhaps no surprise that people are increasingly open to products claiming even the slightest hint of promise, however u
Medical Foods—Food for Thought, But Think Twice
While the AD field awaits a bona fide drug that goes beyond temporary relief of symptoms, patients may be increasingly open to products claiming even the slightest hint of promise...
Research Brief: Glatiramer Slows Progression From High Risk to MS
A drug used to prevent relapse of multiple sclerosis can also prevent people at risk from developing the full disease, according to a report by The Lancet...
Medical Foods—Fallback Option for Elusive AD Drug Status?
Defined by the FDA in 1988, medical foods are a special class of therapeutic agent that fall somewhere in between unregulated food supplements and FDA-approved drugs...
Paris: Macro-roles for MicroRNAs in the Life and Death of Neurons
The simple story of gene transcription into messenger RNA (mRNA) and subsequent translation into a protein has recently become considerably more complicated...
Dimebon: Bright Star or Black Hole?
Dimebon appears as one bright light in a field of less-than-stellar clinical trial results of late...
Amber Dance Interviews Stephen Cohen
Amber Dance Interviews Stephen Cohen
Fondation André-Delambre, 2009 Symposium on Amyotrophic Lateral Sclerosis
Québec: Stem Cells in ALS Update Québec: Transporters, Antibodies Offer Potential ALS Therapies Québec: STOMPing on Inclusions May Reveal their True Identity Québec: Chromogranins Help SOD1 Do Its Dirty Work Researchers need to meet each year to advance t
Québec: Chromogranins Help SOD1 Do Its Dirty Work
Mutant superoxide dismutase 1 (SOD1) has been linked to one-fifth of inherited cases of ALS, where its misfolded form appears to damage motor neurons...
Not So Neighborly: Amyloid Plaques Cripple Nearby Neurons
One look at neurons surrounding amyloid plaques shows they are not normal; however, do outward appearances translate to functional problems inside cells in vivo?...
Québec: STOMPing on Inclusions May Reveal their True Identity
The nervous systems of people with neurodegenerative disease are often pocked with tiny inclusions, which are packed with a variety of proteins, many still unidentified...
Research Brief: Genomewide Studies Uncover Genetic Links to Autism
Semaphore may be a dying art, but the gene for semaphorin 5A (SEMA5A) could spark new life into the hunt for genetic causes of autism...
Safety of Cholinesterase Inhibitors Under Scrutiny
Epidemiologists have found that elderly people starting on cholinesterase inhibitors had twice the risk of hospitalization due to low heart rate (bradycardia)...
Québec: Transporters, Antibodies Offer Potential ALS Therapies
The doctor’s toolkit for amyotrophic lateral sclerosis is pathetically small—only one drug, riluzole, is approved for the disease, and its effects are hardly blockbuster...
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