St. Louis: ApoE—Receptors, Theories and Therapies
ApoE stands out for a frustrating mark of distinction...
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ApoE stands out for a frustrating mark of distinction...
The apolipoprotein E gene is the strongest genetic risk factor for late-onset Alzheimer disease...
Sifting through the genome has netted several mutations responsible for motor neuron diseases, but scientists still cannot explain the cause for most incidences...
Bethesda: Dawn of the Epigenetics Era Bethesda: The Methylated Brain Bethesda: "Ome" Sweet "Ome"—Epigenome Joins Genome, Proteome Epigenetics, the "software" that interprets information stored in the DNA "hardware,"
Histone acetylation is a particularly intriguing epigenetic mark, in part because it changes dynamically...
CLU, CR1, and PICALM emerge again as late-onset AD risk genes in a large case-control association study...
Conventional wisdom says that Down syndrome (DS) goes hand-in-hand with intellectual disability—but what if that was not true?...
A growing body of evidence agrees that FAD-PS mutants are connected to dysregulated calcium signaling in the brain...
Methylation patterns being strongly influenced by the genetic makeup of the individual was taken up at the workshop...
Voltage-gated calcium channels swing open with passing action potentials, allowing calcium ions into the cell, and slide shut when the membrane depolarization has passed...
A study found that after two years, AD patients on a comprehensive care plan fared no better than study participants receiving standard care at memory clinics...
Occam’s razor, as the maxim is now known, may not cut it every time, but as applied to γ-secretase...
Epigenetics, the study of how modifications to DNA and chromatin regulate the activity of genes, is the hot new thing in bioscience...
PatientsLikeMe reports that its users found benefits including enhanced understanding of their symptoms and side effects of medication...
Clustering around synthetic Aβ oligomers embedded in the cell membrane, metabotropic glutamate receptors unleash an influx of calcium that is toxic to neurons...