Lifting Sugar Blockade Leads to Axon Regrowth
A major challenge for achieving nerve regeneration following an injury to the adult brain and spine is the presence of numerous proteins that block the growth of axons across the injury site...
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Mitochondrial Damage in Alzheimer's Disease
A closer look at mitochondria in Alzheimer's disease confirms that oxidative damage to these cellular power plants is a central feature of the disease, according to a report in the May 1 issue of the Journal of Neuroscience...
More on a Glial Role in Neuronal Signalling
Two reports in tomorrow's Science add to a growing body of evidence that glial cells play more than a "housekeeping" role and are essential for neuronal signalling...
Unraveling Metabolic Pathways
In a prime example of what science can accomplish in the "post-genomic" era, researchers have pieced together the functions of a variety of genes involved in a yeast metabolism pathway...
Ultimate Stem Cell in Adult Bone Marrow?
Stem cells from the bone marrow of adults may be as flexible as embryonic stem cells, according a study in the current issue of Cell. Researchers at Yale, New York University, and Johns Hopkins found that these cells...
Molecules for Remote Memories
Permanent memories are thought to be stored in the cortex, but little is known about the processes that incorporate memories into cortical . Now Alcino J. Silva and colleagues, have discovered a molecular manipulation that affects memory...
Mismatch Between Gene and Protein Sequence Data
The path from identifying a genome sequence to pinpointing the contribution of each gene is beset with pitfalls. In a Brief Communication [in today's Nature], researchers describe discrepancies...
Immunological and Neuromuscular Synapses Share Ingredient
The aggregating protein called agrin is a component of two quite different types of synapses: synapses in the neuromuscular junction and the immunological synapse between T cells and antigen-presenting cells...
D'Adamio Is This Year's Alzheimer Award Winner
The Journal of Alzheimer's Disease has awarded the 2001 Alzheimer Medal to Luciano D'Adamio for his article, "Generation of an apoptotic intracellular peptide by γ-secretase cleavage of Alzheimer's amyloid-β protein precursor,"...
The Switch That Turns on Neural Stem Cell Differentiation?
A study in the June issue of Nature Neuroscience points a finger at proteins of the Shc family as the critical link in signaling neural stem cells to either remain in their pluripotent form or differentiate into mature neurons...
Protein Aggregates Block Disposal Mechanism
Aggregates of proteins are a common feature in many neurodegenerative diseases, including Alzheimer's, Parkinson's, Huntington's, fronto-temporal dementia and ALS...
Neprilysin Role in Amyloid Clearance
While much Alzheimer's research has focused on mechanisms that result in the formation of amyloid plaques, a growing body of evidence indicates that processes that break down Aβ are just as important...
Lack of Macrophage Protein Protects ApoE-Knockout Mice from Atherosclerosis
Obesity and its frequent cousin, insulin-resistant diabetes, so clearly increase the risk for atherosclerosis that the whole disease complex has been called metabolic syndrome...
γ-Secretase and Notch: Inhibitor Hits Both, Impairs T Cell Development
The γ-secretase enzyme activity is a therapeutic target in Alzheimer's disease. Yet its promise of lowering the Aβ42 burden has been under a cloud since1999, when Bart De Strooper and other scientists found that the enzyme...
Integrin Helps Adult Neurons Grow Like Newborn Ones, at Least in a Dish
Most research trying to coax adult central nervous system neurons into repairing nerve injury focuses on the environment through which regenerating neurons have to extend new growth cones and axons. A study published today in the Journal of Neuroscience approaches this problem differently...
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