Aβ and Phospho-tau: Strange Bedfellows Get Intimate at Synapses
At first glance, the pair of proteins that form the key pathological features of Alzheimer disease seem quite an odd couple...
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At first glance, the pair of proteins that form the key pathological features of Alzheimer disease seem quite an odd couple...
Human memory is one of the last great biological mysteries...
Among the plethora of factors that might serve as useful biomarkers for AD, perhaps none draws as much scrutiny as plasma amyloid-β...
Recent work indicates that CSF BACE activity is significantly increased in people with AD...
Healthy aging relies on proper function of the transcription factor p53...
Hopping off the couch and into the gym helps both heart and mind, even in seniors at risk for dementia...
The hopes for treating AD by inhibiting the amyloid-producing enzyme β-secretase (BACE) rest largely on results obtained in mice...
Researchers report a new role for certain presenilin-1 mutations that cause early-onset familial Alzheimer disease (eFAD)...
Amyloid-β (Aβ) peptides in cerebrospinal fluid are among the few established molecular signs of impending Alzheimer disease...
While the media focuses on the next potential billion-dollar pharmaceutical treatment of AD, other investigators have been quietly cooking up alternative approaches...
Two anti-amyloid approaches—PBT2 and IVIg—came out with Phase 2 data at ICAD...
At the International Conference for Alzheimer’s Disease, several investigators presented data on compounds in Phase 2...
The newest potential protective factor for Alzheimer’s might be wrapped around your ring finger...
The development of tau-based drugs for AD depends on a deeper understanding of how tau begins to run amok in the first place...
Two papers out this week focus on mitochondria in neurodegeneration in general and Alzheimer disease in particular...