Parkinson Protector: Pink1 Regulates Calcium, Cell Survival
PTEN-induced putative kinase 1, or Pink1, defends cells from reactive oxygen species (ROS) by controlling mitochondrial calcium levels...
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PTEN-induced putative kinase 1, or Pink1, defends cells from reactive oxygen species (ROS) by controlling mitochondrial calcium levels...
Several studies add some ifs, ands, and buts to the general notion that obesity, diabetes, and their comorbidities increase risk for dementia...
Scientists have discovered a recessive mutation in β amyloid precursor protein that causes early-onset Alzheimer disease in two siblings from a small south Italian village...
Two things you can find on any Alzheimerologist’s wish list are better drug targets and better diagnostics...
TAR DNA binding protein-43 has risen from relative obscurity to become a superstar in studies of frontotemporal lobar degeneration and amyotrophic lateral sclerosis...
Scientists have figured out how to induce pluripotency in differentiated cells, then erase their tracks, leaving little or no scar in the genome of the resulting iPS cells...
You can never turn back the clock, but you can protect against the dementia risk of advancing age...
The Aβ42 peptide may self-aggregate to form fibers with a structure profoundly different from those made of its less pathogenic cousin Aβ40...
A proteomic analysis has revealed a previously unknown additional subunit of the AMPA-type glutamate receptor (AMPAR)...
Glia, once the ignored country cousins of the neurons that scientists were really interested in, continue to show that they, too, are sophisticated players in health and disease...
Accumulation of the α-synuclein protein spells death for neurons in Parkinson disease and other synucleinopathies...
Could a new twist to anti-amyloid immunotherapy solve some of the controversial issues in passive immunization?...
Scientists have uncovered a fresh clue in the mystery that is amyotrophic lateral sclerosis...
Finding Aβ oligomers bound to cellular prion (PrPc) was absolutely unexpected...
Considering how nasty amyloid plaques can be to nearby neurons, it should come as no surprise that these clumps of brain Aβ also fluster astrocytes...