Aβ42 molecules assume an S-shaped configuration within fibrils. The structure varies markedly from that adopted by Aβ40.
A stem cell model suggests the β-secretase-generated C-terminal fragment of the amyloid precursor protein raises tau protein levels.
A discontinued β-secretase blocker reportedly quieted inflammation and cleared amyloid plaques by way of microglial activation.
Knockout mice lived to old age with mild brain abnormalities but no sign of motor neuron disease.
Davies, Sperling Share 2015 Potamkin Prize New PET Tracer Tracks Preclinical Movement Disorders Neurodegenerative Proteins In the Skin Could be Diagnostic The 67th American Academy of Neurology conference drew more than 12,000 attendees to Washington, D.C ...
Several different striatal markers may help researchers track early deterioration in Huntington's and Parkinson’s diseases.
People with at least 16 years of education are less likely to accumulate markers of neurodegeneration in their brains, says a cross-sectional study.
Researchers identify N-terminally extended Aβ peptides that are toxic to synapses and rise after BACE1 inhibition, though whether they occur in human disease remains unclear.
The approach plays neuroinflammation against neurodegeneration. It may be too risky for people because it would instigate multiple sclerosis, but yields information on the choroid plexus.
Researchers report the highest resolution structure to date for γ-secretase, the multisubunit complex that churns out Aβ.
As DIAN Plans Trial Number Two, the Goal Is to Go Big DIAN-TU Pharma Consortium NexGen Trial Meeting ...
A NexGen prevention trial in familial Alzheimer’s mutation carriers will shoot for flexible testing of high doses and drug combinations.
A protein instigates axon degeneration by promoting destruction of the essential enzyme cofactor, NAD+.
In a Solomonic move, a prestigious prize for research in neurodegenerative disease goes to a veteran tauist and a self-professed inhabitant of “amyloid land.”
A new study suggests that tau oligomers as small as trimers enter neurons and corrupt native tau proteins inside.