Research Brief: Mutations in Tau Kinase Cause Neurodegenerative Disease
Mutations in a tau kinase gene have been tied to the neurodegenerative disease spinocerebellar ataxia type 11...
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Mutations in a tau kinase gene have been tied to the neurodegenerative disease spinocerebellar ataxia type 11...
At the l7th Annual Marian S. Ware Neurodegenerative Diseases Research Retreat, hosts Virginia Lee and John Trojanowski pulled together a formidable roster of speakers...
Acetylcholinesterase inhibitor drugs are unable to slow progression from mild cognitive impairment (MCI) to dementia...
Using a phage display technique to identify conformation-specific antibodies in vitro, researchers have produced a novel amyloid-binding antibody...
On the one hand, research studies have amassed a laundry list of factors that influence experimental amyloid deposition in mouse models of amyloidosis...
Sangram Sisodia’s group presented new data that exemplify how the expanding field of environmental enrichment and adult neurogenesis has inspired AD research...
Microglia play an important, if controversial, role in Alzheimer disease (AD)...
If our summary on Aβ oligomers from the recent conference of the Society for Neuroscience delivered an overdose of news on synaptotoxic Aβ, take this story as an antidote...
It may be a surprising idea, but it is becoming clearer that complement factors and MHC Class I proteins are regulators...
A major point of confusion in this field has been that different research groups are working with different kinds of Aβ oligomer...
Neurochem announced last week that it would halt development of tramiprosate (Alzhemed)...
Of all other presentations on Aβ oligomers, a talk by Takami Tomiyama created the greatest stir in the audience...
Over the past decade, researchers have shifted away from a literal interpretation of Alois Alzheimer’s groundbreaking discovery...
Could the failure of cell cycle regulation be an underlying cause of neurodegenerative disorders, including Alzheimer disease?...
The first AD vaccine to be tested in humans, Elan’s AN-1792, stalled in phase 2b...