Overworked HDACs Leave Transcriptional Posts to Push DNA Repair
In discussions of what goes awry during neurodegeneration, the words genome stability, cell cycle, and DNA repair often come out in the same breath...
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In discussions of what goes awry during neurodegeneration, the words genome stability, cell cycle, and DNA repair often come out in the same breath...
In the spinal cord, as in life, too much of a good thing can be detrimental...
Researchers are not shy about putting new therapies through preclinical paces...
Researchers show that cultured human motor neurons are killed by rodent or human astrocytes expressing a mutation that causes ALS...
Widely seen as the molecular trigger for a cascade of changes leading to AD, Aβ lurks within the brains of many cognitively normal seniors, too...
In its textbook version, gene transcription is a one-way street...
Kieth A. Crutcher Interviews Rudy Tanzi
The mSOD1 mouse, harboring a mutated human superoxide dismutase (SOD1) gene, has long held the spotlight as the model of choice for ALS...
Once thought to be a simple go-between, RNA is recently attracting much more attention as an important regulator of gene expression in its own right...
Loaded with promise and disappointment, the roller-coaster tale of Alzheimer disease vaccine development has raised hopes and dampened some...
Gumming up the brain years before a person may notice memory loss or other hints of Alzheimer disease, amyloid-β (Aβ) has fueled much of AD research...
Neprilysin, one of a handful of proteases known to degrade amyloid-β (Aβ), might seem an attractive therapeutic for Alzheimer disease...
Older people who are buying and taking ginkgo biloba pills to ward off Alzheimer disease can save their money...
As representatives of the world’s 20 richest nations were meeting in Washington, DC, more than 31,000 scientists began arriving a few blocks away...
Two groups report the crystal structure of the calcium-dependent protease calpain in complex with its endogenous inhibitor protein, calpastatin...