Off BACE: Lack of Secretase Causes Seizures in Knockout Mice
A potential therapeutic strategy for Alzheimer disease (AD) is to inhibit the BACE enzymes that kickstart processing of amyloid precursor protein (APP) to form Aβ...
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A potential therapeutic strategy for Alzheimer disease (AD) is to inhibit the BACE enzymes that kickstart processing of amyloid precursor protein (APP) to form Aβ...
Microarrays tantalize investigators with the promise of a new smorgasbord of genes to explore and proteins to target with therapeutics...
During the late 1980s and the 1990s, tissue grafts, chosen to replace lost dopaminergic neurons, seemed to show great promise for the treatment of Parkinson disease...
Misfolded proteins can gum up the cell’s works by glomming together and boosting inflammation...
ApoE stands out for a frustrating mark of distinction...
The apolipoprotein E gene is the strongest genetic risk factor for late-onset Alzheimer disease...
Sifting through the genome has netted several mutations responsible for motor neuron diseases, but scientists still cannot explain the cause for most incidences...
Bethesda: Dawn of the Epigenetics Era Bethesda: The Methylated Brain Bethesda: "Ome" Sweet "Ome"—Epigenome Joins Genome, Proteome Epigenetics, the "software" that interprets information stored in the DNA "hardware,"
Histone acetylation is a particularly intriguing epigenetic mark, in part because it changes dynamically...
CLU, CR1, and PICALM emerge again as late-onset AD risk genes in a large case-control association study...
Conventional wisdom says that Down syndrome (DS) goes hand-in-hand with intellectual disability—but what if that was not true?...
A growing body of evidence agrees that FAD-PS mutants are connected to dysregulated calcium signaling in the brain...
Methylation patterns being strongly influenced by the genetic makeup of the individual was taken up at the workshop...
Voltage-gated calcium channels swing open with passing action potentials, allowing calcium ions into the cell, and slide shut when the membrane depolarization has passed...
A study found that after two years, AD patients on a comprehensive care plan fared no better than study participants receiving standard care at memory clinics...