Permanent memories are thought to be stored in the cortex, but little is known about the processes that
incorporate memories into cortical . Now Alcino J. Silva and colleagues, have discovered a molecular manipulation that affects memory...
The path from identifying a genome sequence to pinpointing the contribution of each gene is beset
with pitfalls. In a Brief Communication [in today's Nature], researchers describe discrepancies...
The aggregating protein called agrin is a component of two quite different types of synapses: synapses in the neuromuscular junction and the immunological synapse between T cells and antigen-presenting cells...
The Journal of Alzheimer's Disease has awarded the 2001 Alzheimer Medal to Luciano D'Adamio for his article, "Generation of an apoptotic intracellular peptide by γ-secretase cleavage of Alzheimer's amyloid-β protein precursor,"...
A study in the June issue of Nature Neuroscience points a finger at proteins of the Shc family as the critical link in signaling neural stem cells to either remain in their pluripotent form or differentiate into mature neurons...
Aggregates of proteins are a common feature in many
neurodegenerative diseases, including Alzheimer's, Parkinson's, Huntington's, fronto-temporal dementia and ALS...
While much Alzheimer's research has focused on mechanisms that result in the formation of amyloid plaques, a growing body of evidence indicates that processes that break down Aβ are just as important...
Obesity and its frequent cousin, insulin-resistant
diabetes, so clearly increase the risk for atherosclerosis that the whole disease complex has been called metabolic syndrome...
The γ-secretase enzyme activity is a therapeutic target in Alzheimer's disease. Yet its promise of lowering the Aβ42
burden has been under a cloud since1999, when Bart De Strooper and other scientists found that the enzyme...
Most research trying to coax adult central nervous system neurons into repairing nerve injury focuses on the environment through which regenerating neurons have to extend new growth cones and axons. A study published today in the Journal of Neuroscience approaches this problem differently...
Thirty European Alzheimer's Disease Centers of Excellence and one nongovernmental organization, Alzheimer Europe, have established a network to carry out multicentre interventional trials under the auspices of the European Commission...
It has been clear for a number of years that iron accumulates in areas such as the hippocampus in Alzheimer's disease and the substantia nigra in Parkinson's disease. Just what this means is...
As the political debate about stem cell research heats up once again, scientists continue to wrestle with the most fundamental questions about these cells: Where do they come from? Are the stem cells...
In the search for those mostly still-elusive SNPs that are widely thought to predispose to complex, multigenic diseases such as schizophrenia and heart disease, one technical hurdle that slows down the search is the sheer amount of sequencing required...
Pretreatment with the hormone erythropoietin (EPO) can protect neurons in models of neurodegenerative and stroke-related cell death, according to a paper in today's Nature...