Dimebon for HD—A Hint of Cognitive Benefit?
The results of the first U.S. Phase 2 trial for Dimebon in Huntington disease are finally out in print...
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The results of the first U.S. Phase 2 trial for Dimebon in Huntington disease are finally out in print...
When judging the utility of cerebrospinal fluid biomarkers in Alzheimer disease, it may be less a question of if, but rather when and in whom...
The protein aggregates that brew discord in several neurodegenerative diseases may have some troublemakers in common...
Might amyloid plaques suck the life out of neurons by trapping metal ions required for synaptic transmission?...
Neuronal stem cells are proving to function like capable paramedics, coming to the rescue of degenerating neurons in multiple animal models of disease...
Mitochondria take the stage in three recent papers...
There are times in the course of scientific enterprise when researchers must re-evaluate their hypotheses in the face of new, unexpected data...
The new animal models for TDP-43 proteinopathies, a series of related neurodegenerative diseases, are coming out at a fast and furious rate...
The cellular prion protein has received a lot of attention recently for its potential role in amyloid-β (Aβ) toxicity...
Death and taxes are reputedly inevitable, though death and receptors may be more interesting to Alzforum readers...
Bigger, smarter, and more amenable than mice to the imaging techniques that are rapidly becoming indispensable in AD research, rats could be a valuable model for studying AD...
Gizem Donmez reported that SIRT1 might protect against AD by boosting ADAM10 (aka α-secretase) and promoting non-amyloidogenic processing of Aβ APP...
While too little calcium can trigger bone problems, insufficient magnesium may spell trouble for your brain...
A fruit fly is joining the menagerie of TDP-43 animal models, bringing the power of <em>Drosophila</em> genetics to the lab bench...
NMDA receptors populate the synapse, where they participate in nerve signaling and promote cell survival pathways; but those same receptors can activate apoptosis...