Keystone: Loss Versus Gain—Mutations a Drag on γ-Secretase
A third area of γ-secretase research that drew attention at the Keystone conference is the hotly debated question of how presenilin mutations cause familial Alzheimer disease...
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A third area of γ-secretase research that drew attention at the Keystone conference is the hotly debated question of how presenilin mutations cause familial Alzheimer disease...
Investigators described joint new research on how the lipid composition of the membrane influences the enzyme activity of γ-secretase...
Does a seven-year-old mouse model that mirrors schizophrenia traits bring good luck?...
Fiendishly complicated, γ-secretase inspires both awe and weariness...
The road to reliable preclinical AD biomarkers has proven long and difficult...
What is going on in older folks who seem to do fine with amyloid-peppered brains?...
Keystone: γ Slowly Relinquishes Its Secrets Keystone: Lipids Grease γ-Secretase Activity Keystone: Loss Versus Gain—Mutations a Drag on γ-Secretase Fiendishly complicated, γ-secretase has proved a formidable foe to the structurally minded scientist. But g
A flurry of clinical trial news this past week brought mostly disappointment...
Scientists in Germany have created a membrane-tethered version of a β-secretase inhibitor...
Increased β-site cleavage enzyme 1 (BACE1) is one plausible risk for sporadic Alzheimer disease, but what causes this increase?...
One of the big surprises at this year’s Human Amyloid Imaging meeting was the finding that a significant proportion of healthy controls are PIB-positive...
HAI Chicago: PIB in Healthy People HAI Chicago: Can PIB Predict Cognitive Decline? HAI Chicago: PIB and Aβ Show Regional Nuances and Sleep-Wake Rhythm HAI Chicago: Not Just PIB—Other PET Tracers in Clinical Pipeline Human Amyloid Imaging 2008
Many studies using Pittsburgh Compound-B (PIB) have found a fair percentage of normal elderly walking around with heads full of amyloid...
Two genetics papers this month add to the mounting evidence that TAR DNA binding protein (TDP-43) is a key player in ALS and not just an innocent bystander...
In the April 16 Journal of Neuroscience, researchers give a vivid account of the microglia/plaque relationship...