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Brian Balin and colleagues at the Philadelphia College of Osteopathic Medicine presented data showing that chlamydia isolated from Alzheimer’s brain, cultured, and then sprayed into the noses of young wild-type BALB/c mice can cause progressive deposition of amyloid plaques...
Are two new proteins the missing links to understand the γ-secretase complex? Research presented today at the 8th International Conference on Alzheimer’s Disease and Related Disorders in Stockholm suggests as much. Are more components yet to be discovered?
Tony Wyss-Coray and colleagues are reporting that disabling the complement cascade, known for its role in innate immunity, causes hippocampal neurodegeneration and exacerbates amyloid deposition. Could this be a way in which microglial activation is beneficial in AD?
More epidemiological data is being reported at the 8th International Conference on Alzheimer’s Disease and Related Disorders in Stockholm to strengthen the association between statin use and lower risk for AD.
Coverage by Keith Crutcher from the Genetics Symposium at the 8th International Conference on Alzheimer’s Disease and Related Disorders in Stockholm.
The Aβ peptide that circulates in the periphery is degraded not primarily by the kidney, but in the liver, scientists report at the 8th International Conference on Alzheimer’s Disease and Related Disorders in Stockholm.
Over the past decade, new technologies have led to an explosion in the generation of biological data, leaving scientists wishing for a simple way to assimilate and then present the new information...
Researchers at the Albert Einstein College of Medicine in New York demonstrate the use of fluorescence in situ hybridization, or FISH, to measure multiple transcription events in vitro...
More news updates from the 8th International Conference on Alzheimer’s Disease and Related Disorders in Stockholm: In a wide-ranging and eloquent presentation, Christian Haass provided several experimental proofs that a small amount of presenilin is detected at the plasma membrane...
Ever since Cao and Sudhof provided the first evidence that the intracellular domain of APP (AICD) translocates to the nucleus and may be involved in transcriptional regulation, there has been a reawakening of interest in APP function...
Humans who live longer display the same biomarkers found in laboratory animals who have restricted caloric intake. However, because these human subjects weren't actively restricting their caloric intake, there may be other ways to increase life span in humans...
David Altshuler and colleagues at the Whitehead Institute report that only a small fraction of SNPs arise by random mutation and that most SNPs are inherited. These findings should have a profound effect on those researchers hunting for genetic clues to disease....
Research reported in the online Nature Medicine reinforces the potential of adult stem cells to repair the damaged or diseased brain, but it also points out the extent to which these cells are dependent on a healthy microenvironment.
Could analyzing gene duplications help identify those elusive Alzheimer's genes?
This week's issue of Nature features two articles that point to ways in which the targeting of molecules associated with maintenance of cognitive function might one day help boost these functions in both normal and demented older adults.
