Obesity and its frequent cousin, insulin-resistant
diabetes, so clearly increase the risk for atherosclerosis that the whole disease complex has been called metabolic syndrome...
The γ-secretase enzyme activity is a therapeutic target in Alzheimer's disease. Yet its promise of lowering the Aβ42
burden has been under a cloud since1999, when Bart De Strooper and other scientists found that the enzyme...
Most research trying to coax adult central nervous system neurons into repairing nerve injury focuses on the environment through which regenerating neurons have to extend new growth cones and axons. A study published today in the Journal of Neuroscience approaches this problem differently...
Thirty European Alzheimer's Disease Centers of Excellence and one nongovernmental organization, Alzheimer Europe, have established a network to carry out multicentre interventional trials under the auspices of the European Commission...
It has been clear for a number of years that iron accumulates in areas such as the hippocampus in Alzheimer's disease and the substantia nigra in Parkinson's disease. Just what this means is...
As the political debate about stem cell research heats up once again, scientists continue to wrestle with the most fundamental questions about these cells: Where do they come from? Are the stem cells...
In the search for those mostly still-elusive SNPs that are widely thought to predispose to complex, multigenic diseases such as schizophrenia and heart disease, one technical hurdle that slows down the search is the sheer amount of sequencing required...
Pretreatment with the hormone erythropoietin (EPO) can protect neurons in models of neurodegenerative and stroke-related cell death, according to a paper in today's Nature...
While therapeutic Aβ antibodies are wending their way through clinical trials, researchers studying other offending brain proteins have been racing to work out similar strategies...
In the August 16 Nature, scientists in the laboratory of Perry Bartlett, at the Walter and Eliza Hall Institute of Medical Research, Victoria, Australia, report the successful isolation of multipotent stem cells from adult mice...
Spinal muscular atrophy with respiratory distress type 1 (SMARD1), a life-threatening disease that strikes infants as young as four weeks, is due to loss of neurons in the anterior horn of the spinal cord...
Astrocytes are the stem cells that generate new neurons in the mammalian hippocampus, according to a report in the September 15 Journal of Neuroscience. This result appears to match results from the subventricular zone...
Investigators working to detect subtle changes in cognitive ability form part of the ongoing effort to develop ways of identifying people who will go on to develop AD in the future...
The National Institute of Aging has awarded $54M over five years, one of its largest-ever grants, to the Alzheimer's Disease Cooperative Study (ADCS). Directed by Leon Thal at the University of California, San Diego, this consortium of centers...