Evidence of Genetic Factor in Late-Onset Parkinson's
Mutations in the genes for α-synuclein and parkin have been linked to early-onset Parkinsonism, but the role of genetics in the far more common late-onset disease has been less clear...
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News Summary from the 40th Annual Meeting of The American Society for Cell Biology
The 40th ASCB meeting began its grand kick-off on Saturday December 9 with an opening symposium by four Nobel Laureates, J. Michael Bishop, Joseph Goldstein, Michael Brown, and Harold Varmus. Bishop summarized his discovery of proto-oncogenes...
More Vaccine Results in Nature
A trio of articles will appear in tomorrow's issue of Nature, reporting that Aβ peptide immunization reduces a memory deficit in transgenic mouse models of AD...
Blocking Aβ's Oxygen Radical Producing Power
A study presented earlier this week at the 2000 International Chemical Congress of Pacific Basin Societies in Honolulu found that by manipulating the structure of amyloid-β, it was possible to reduce the peptide's ability...
New DNA Array Method Paves Way to "User's Manual" for Master Genes
In today's issue of Science, researchers at the Whitehead Institute and Corning Inc. describe a new microarray technique that can decipher the function of master switches in a cell by identifying the set of genes they control across the entire genome...
Selegiline Does Not Increase Parkinson's Death Rate
The drug selegiline, thought to be neuroprotective, has been used to treat Parkinson's disease for the past 25 years, but a report a few years ago suggested that the drug could accelerate death in patients taking it...
GFAP Mutation in Alexander's Disease
The cause of Alexander's disease, a very rare, inherited CNS disorder, has been traced to the gene for glial fibrillary acidic protein (GFAP), according to a report published in this month's Nature Genetics...
Glia May Regulate Synaptic Formation and Transmission
Glial cells quietly play a much bigger role than ever imagined, according to an article in today's issue of Science. Ben Barres and colleagues at Stanford report that astrocytes exert a powerful influence on communication between neurons...
Defect in Iron Metabolism Leads to Neurodegeneration
Deleting a critical gene for iron metabolism leads to selective neurodegeneration, according to a study in this month's Nature Genetics. When researchers ablated the gene for iron regulatory protein 2 (IRP2), they produced...
Amyloid Not an Aberration?
Aggregated proteins, or amyloids, are seen in a wide variety of neurodegenerative diseases, including Alzheimer's and Creutzfeldt-Jakob (CJD) disease. Such aggregates are generally considered to be aberrant formations...
Mouse (Gene) Trap
Understanding the mechanisms regulating brain wiring has until now relied on biochemical purification approaches in vertebrates and genetic approaches in invertebrates to identify molecular clues. This week...
"Mad Yeast"?
This week Peter Chien and Jonathan Weissman of the University of California, San Francisco, explain how they used two species of yeast (and an artificial yeast prion protein to investigate how prions jump the species barrier...
Neurogenesis and Memory
It is now generally accepted that new neurons are generated in the adult mammalian brain, but until now it has been unclear whether or not these neurons are essential for memory formation...
Mitochondrial Exports
A British and German team has made the surprising discovery that the cell's mitochondria can export peptides into their surrounding environments. Much is known about how mitochondria import proteins, but the role of this unexpected export mechanism...
A Potential Mechanism for Cell Toxicity in Huntington's
The abnormal form of the protein huntingtin may exert its toxic effects on neurons in Huntington's disease by interfering with a protein essential for gene transcription, according to a study published in this week's issue of Science...
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