ALS—Bridging the Way to Therapy
Designed to speed transport and communication, bridges may also be useful for slowing disease. Researchers suggest as much in their review of one promising strategy for slowing the progression of ALS...
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Designed to speed transport and communication, bridges may also be useful for slowing disease. Researchers suggest as much in their review of one promising strategy for slowing the progression of ALS...
As part of the tangled web of pathology that leads to Alzheimer’s disease, inflammation is associated with local immune responses. For example, recent data indicate that both AD patients and elderly healthy people have...
Conventional wisdom says too much stress is a dangerous thing, weakening the heart, immune system, and perhaps the brain...
Researchers have been interested in the connections between stress and Alzheimer’s disease for years, but hard data remained elusive at first...
This week, two independent groups of academic researchers call for more transparency in the conduct of clinical trials...
The intramembrane protease activity of γ-secretase is a prime target for therapeutic strategies aimed at treating Alzheimer disease by...
A troika of papers provides evidence that γ-secretase is primarily localized intracellularly and needs the C-terminus of PEN-2 for complete integration...
Small interfereing RNAs are a hot new tool to manipulate gene expression. Read here about how to apply this method to primary neuronal cultures.
This story closes our coverage of the 10th International Conference on Alzheimer’s Disease and Related Disorders, held last July in Madrid. See <a href="/sites/default/files/legacy/images/new/LaFerla1460.pdf">PDF</a> of this story.
In today’s Science, researchers report that miRNAs...
Results from a mouse model of chronic neuroinflammation suggest that...
Research shows that from delicate yeast to mammalian gourmands, restricting caloric intake can dramatically increase longevity...
You can never turn back the clock, but you can protect against the dementia risk of advancing age...
In recent years, mounting evidence has pointed to soluble oligomers of Aβ, rather than amyloid fibrils, as the most toxic species in AD...
How does a nice (that is, soluble and relatively unstructured) protein like tau end up rigidly locked into paired helical filaments and neurofibrillary tangles?...