Affibodies—Putting the β in Aβ?
Aβ is infamous for its ability to form large fibrils rich in β-sheet secondary structure...
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Aβ is infamous for its ability to form large fibrils rich in β-sheet secondary structure...
Overexpressing a single anti-apoptotic protein on top of an already triple-transgenic model of Alzheimer disease (AD) rescues amyloid and tau pathology...
Companies large and small are targeting amyloid-β (Aβ), guided by the hypothesis that if they can decrease its concentration in the brain, then they will slow down disease...
Having one parent with Alzheimer disease is hard enough; having two must be devastating...
The cyclin-dependent kinase Cdk5 has diverse functions in the brain, and has been implicated in Alzheimer disease in multiple contexts...
Researchers provide evidence that the same polyglutamine expansion mutation in ataxin can lead to simultaneous gain and loss of function...
Fragments of amyloid-β precursor protein (APP) previously associated with Alzheimer disease pathology are present at dramatically higher levels in the brains of young, perfectly normal adults...
New work implicates a novel endocytic pathway in the internalization of APP...
Thanks to a decade of work by advocates for public access, today a few keystrokes is all it takes to pull up a wealth of information about ongoing clinical trials...
Much of the data generated from drug trials on human volunteers stays hidden from view, sometimes to the detriment of patients...
In ALS and other neurodegenerative disorders, a newer player could be joining the current star under the limelight...
The capacity to generate action potentials, prime purview of neurons, is actually not exclusive to those cells...
Only one in 10,000 people gets to be serenaded with the “Happy Birthday” song for the 100th time...
Mitochondria get more than their fair share of the blame for neurodegeneration...
The MetLife Foundation recognized three scientists who advanced knowledge of the β- and γ-secretase enzymes...