Boston: Neuroprotective Peptide Inches Forward in Clinic
A trickle of data is starting to emerge from a Phase 2 clinical trial of a neuroprotective peptide...
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A trickle of data is starting to emerge from a Phase 2 clinical trial of a neuroprotective peptide...
At the Alzheimer’s Disease conference, Robert Vassar briefed the audience on his group’s latest work on the β-secretase BACE1...
Though ApoE4 is the most prevalent genetic risk factor for Alzheimer disease, its role in pathology has been tricky to pin down...
Keeping mitochondria trim and fit is good for your health, yet in Parkinson disease (PD) these organelles are all but healthy...
A third area of γ-secretase research that drew attention at the Keystone conference is the hotly debated question of how presenilin mutations cause familial Alzheimer disease...
Investigators described joint new research on how the lipid composition of the membrane influences the enzyme activity of γ-secretase...
Does a seven-year-old mouse model that mirrors schizophrenia traits bring good luck?...
Fiendishly complicated, γ-secretase inspires both awe and weariness...
The road to reliable preclinical AD biomarkers has proven long and difficult...
What is going on in older folks who seem to do fine with amyloid-peppered brains?...
Keystone: γ Slowly Relinquishes Its Secrets Keystone: Lipids Grease γ-Secretase Activity Keystone: Loss Versus Gain—Mutations a Drag on γ-Secretase Fiendishly complicated, γ-secretase has proved a formidable foe to the structurally minded scientist. But g
A flurry of clinical trial news this past week brought mostly disappointment...
Scientists in Germany have created a membrane-tethered version of a β-secretase inhibitor...
Increased β-site cleavage enzyme 1 (BACE1) is one plausible risk for sporadic Alzheimer disease, but what causes this increase?...
One of the big surprises at this year’s Human Amyloid Imaging meeting was the finding that a significant proportion of healthy controls are PIB-positive...