Paper Alert: Energy Deprivation Drives up BACE Translation
One of the talks that has stood out at Alzheimer research conferences this past year will appear in full in the December 26 issue of Neuron...
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Paper Alert—Transcription Factors Regulate Aβ Clearance
Researchers reveal transcriptional mechanisms that may regulate Aβ clearance from the brain...
Virus Slips Through Blood-Brain Barrier to Deliver the Gene Goods
Like a spy on a secret mission, the #9 serotype of adeno-associated virus sneaks through the blood-brain barrier...
Neuron Loss in AD Mouse—Yes, But Not the Cholinergic Kind
One of the shortcomings of most mouse models of Alzheimer disease is that they fail to recapitulate the rampant neurodegeneration that is seen in humans...
Mnemonic Models—Flies, Mice, and Rats Reveal Pathways to Memory
<em>Drosophila</em> have proven a valuable tool for studies of biochemical pathways related to memory and to neurodegenerative disease...
IGF-1 Disappoints in Trials for AD, ALS
November was a dreary month for those who had high hopes for insulin-like growth factor-1 as a treatment for neurodegenerative disorders...
Aβ and SORLA—Partners in Cerebrovascular Crime?
For years there has been a somewhat murky connection between Alzheimer disease and cerebrovascular disease...
Clinical Trials—Could Participant Amenities Boost Enrollment?
A few researchers have turned their attention to an oft-neglected component of clinical trials—the participants themselves...
Society for Neuroscience Annual Meeting 2008
DC: Funding We Can Believe In? Perhaps, But Scientists Must Advocate DC: Aβ Clearance—Roles for MBP, Transcription Factors? DC: Primate, Mouse Studies Sustain Aβ Immunotherapy Hopes DC: New Neprilysin Methods Reduce Brain Aβ DC: Dogs May Provide First Nat
DC: New γ Secretase Inhibitors Hit APP, Spare Notch
Specificity is a big issue for drug makers as side effects due to unpredicted interactions can scuttle potential pharmaceuticals...
Nrf2 Pumps Up Astrocyte Protection of Motor Neurons in ALS Model
Even in the face of mutated Cu/Zn superoxide dismutase (SOD1), sensitive motor neurons can get by with a little extra help from their antioxidant-pumping astrocyte friends...
Are Mad Cows Still a Threat? Time and Genes May Tell
Creutzfeldt-Jakob disease (CJD) is a fatal and transmissible neurodegenerative disease caused by a buildup of misfolded prion proteins in the brain...
Research Brief: Many Alzheimer Deaths Go Unreported
If an end-stage Alzheimer disease patient with difficulty swallowing ends up with a fatal lung infection, does she die from respiratory failure or AD?...
DC: Developing But Debatable—Deacetylase Inhibitors for CNS Disease?
While some neurodegenerative disease therapies focus on signature proteins, a growing number are addressing more fundamentally what sets neurons up for self-destruction...
Overworked HDACs Leave Transcriptional Posts to Push DNA Repair
In discussions of what goes awry during neurodegeneration, the words genome stability, cell cycle, and DNA repair often come out in the same breath...
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