Frustrated ALS Enzyme: SOD1 Sacrifices Structural Stability for Function
For superoxide dismutase 1 (SOD1), the very features that allow the protein to do its job may make it prone to form abnormal aggregates...
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For superoxide dismutase 1 (SOD1), the very features that allow the protein to do its job may make it prone to form abnormal aggregates...
Structural analyses offer insight into how a cancer drug stabilizes a tau pre-messenger RNA structure to curb production of a tau splice form that leads to dementia when made in excess...
Researchers have generated common marmosets that carry a transgene for enhanced green fluorescent protein (EGFP)...
Sometimes in science, a concept lingers unattended in the collective back of researchers’ minds for years...
Researchers coaxed huntingtin proteins to adopt distinct conformations in vitro under different temperatures, and showed that shape in large part determined toxicity...
ADNI: One-year Data Narrow Field of MRI, FDG-PET Approaches ADNI: Mission Creep From Alzheimer Disease to Healthy Senior? Preliminary and mostly unpublished, analysis of one-year data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) is in!
Cholesterol plays the villain in Alzheimer disease as an enabler of the production of toxic amyloid-β (Aβ) peptides, but it may have a second role as well...
The Alzheimer’s Disease Neuroimaging Initiative (ADNI) was originally conceived as an exploratory project to identify the best measures for tracking disease progression...
Alzheimer imaging aficionados gathered for a peek at the latest data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI)...
The oldest and the youngest people are often the most vulnerable to disease. The same might be true for cells...
The efficacy of Iplex is unknown; it is untested in clinical trials, untried in mouse models, and, for the most part, unapproved by the Food and Drug Administration...
The combined belt-and-suspenders approach is renowned for protecting against public humiliation, but it may hold up just as well when used in medicine...
Two recent papers offer clues as to how ALS progresses from onset to inevitable death...
Researchers add another dimension to BDNF biology. They report that CSF BDNF levels drop as people age and are lowest in those with poorest recall...
Amyloid-β (Aβ) oligomers are presumed guilty of killing neurons in Alzheimer disease, but that may not be their only transgression...