Synapses: Aβ and Tau Reside There, Cdk5 Shows Up Again
Two papers out this week focus on synapses, their contents and function, and how amyloid-β (Aβ) might play into both...
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Two papers out this week focus on synapses, their contents and function, and how amyloid-β (Aβ) might play into both...
Like baseball coaches selecting top prospects for their team, geneticists studying Alzheimer disease face a formidable challenge...
Scientists at the Yerkes National Primate Research Center in Atlanta, Georgia, have developed a primate model of Huntington disease...
Once again, clinical trial data suggest that non-steroidal anti-inflammatories (NSAIDs) are non-starters when it comes to preventing dementia...
In spinal muscular atrophy (SMA), researchers have known for some time that motor neurons die for lack of the SMN (survival motor neuron) protein...
The alternative splicing of β-secretase messenger RNA leads to the production of inactive forms of BACE1...
Consider a study in last week’s online PNAS a reminder that one lab’s trash could be another’s treasure...
A new approach to detoxifying the amyloid-β (Aβ) peptide borrows from an unlikely source—the field of cancer drugs...
Peering through the dense thicket of axons and dendrites to figure out what individual neurons are up to in brain tissue is no mean feat...
The arrangement of linked brain regions into functional networks supports complex mental activity...
Hopes of harnessing the immune system to fight Alzheimer disease took another hit...
Boston: Neuroprotective Peptide Inches Forward in Clinic Strategic Research Institute’s Alzheimer Disease Conference
A trickle of data is starting to emerge from a Phase 2 clinical trial of a neuroprotective peptide...
At the Alzheimer’s Disease conference, Robert Vassar briefed the audience on his group’s latest work on the β-secretase BACE1...
Though ApoE4 is the most prevalent genetic risk factor for Alzheimer disease, its role in pathology has been tricky to pin down...