Oldest Old—The New Face of Dementia?
A recent population-based study supports the idea that in the oldest old, the relationship between plaques and tangles, and dementia, may be more legend than substance...
6352 RESULTS
Sort By:
A recent population-based study supports the idea that in the oldest old, the relationship between plaques and tangles, and dementia, may be more legend than substance...
This penultimate article in this Alzforum series reports the call of a founding neurogeneticist to reorganize the genetics of Parkinson’s and related diseases...
This news story on the glucocerebrosidase (GBA) gene closes the Alzforum series on emerging concepts in the neurodegenerative disease spectrum...
The mystery of Huntington disease (HD) is how a toxic protein that is expressed in all the cells in the body kills only a select subset of neurons in the brain...
Scientists wrestling the complexities of α-synuclein fluid biochemistry might be forgiven for looking with some envy to a different protein of the neurodegenerative disease spectrum...
Aggregates of TAR DNA-binding Protein-43 are a bad sign in neurons, where they are found in some forms of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD)...
Presenilins deliver the final cut to unleash the Aβ peptides that form the amyloid plaques that gum up the brains of Alzheimer disease patients...
Well over a decade of research into fluid biomarker candidates has reached a point where a so-called “pathological signature” of amyloid-β and tau proteins is beginning to emerge...
Tangible progress in dealing with spectrum diseases will remain limited until the field comes up with more and better biomarkers of their component proteins...
How to protect the proteins in the cell that protect other proteins—the chaperones...
Current work on distinguishing Alzheimer disease from its cousin dementia with Lewy bodies has underscored one intriguing similarity between the two...
Wnt signaling proteins act as forepersons for synapse assembly in developing animals—but they can be called out of retirement to do the same thing in adults...
Perhaps the biggest, and quintessential, representative of a spectrum neurodegenerative disease is dementia with Lewy bodies (DLB)...
Mutations in the Pink1 gene cause a recessive form of early-onset parkinsonism, and all the evidence points to mitochondria as the prime locus of the damage...
Thomas Gasser of the Hertie Institute in Tuebingen, Germany, presented data that illustrated two emerging concepts in neurodegenerative disease research...