Parkinson Advances: Cloning Cure for Mouse Model, New Gene Identified
Scientists took a step closer to a stem cell treatment for neurodegenerative disease this week...
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Scientists took a step closer to a stem cell treatment for neurodegenerative disease this week...
With the help of simple model organisms, two research groups have come up with dozens of genes that could be tied to pathological events in two major neurodegenerative diseases...
Consider it the final nail. That’s what coauthor Bill Klunk calls a new study in which he and colleagues show direct correlation between postmortem amyloid pathology and live brain imaging using Pittsburgh Compound B (PIB)...
Can sirtuins do no wrong? These NAD+-dependent deacetylases regulate metabolism, keep mitochondria happy, and increase longevity in animals...
Researchers find that mice expressing SOD1 mutations associated with inherited forms of amyotrophic lateral sclerosis (ALS) show vascular defects early in life...
Aβ is infamous for its ability to form large fibrils rich in β-sheet secondary structure...
Overexpressing a single anti-apoptotic protein on top of an already triple-transgenic model of Alzheimer disease (AD) rescues amyloid and tau pathology...
Companies large and small are targeting amyloid-β (Aβ), guided by the hypothesis that if they can decrease its concentration in the brain, then they will slow down disease...
Having one parent with Alzheimer disease is hard enough; having two must be devastating...
The cyclin-dependent kinase Cdk5 has diverse functions in the brain, and has been implicated in Alzheimer disease in multiple contexts...
Researchers provide evidence that the same polyglutamine expansion mutation in ataxin can lead to simultaneous gain and loss of function...
Fragments of amyloid-β precursor protein (APP) previously associated with Alzheimer disease pathology are present at dramatically higher levels in the brains of young, perfectly normal adults...
New work implicates a novel endocytic pathway in the internalization of APP...
Thanks to a decade of work by advocates for public access, today a few keystrokes is all it takes to pull up a wealth of information about ongoing clinical trials...
Much of the data generated from drug trials on human volunteers stays hidden from view, sometimes to the detriment of patients...