It appears that some tauopathies require the presence of neurofilaments for neurodegeneration to occur. In the 15 August Journal of Neuroscience, Virginia Lee, Takeshi Ishihara, and colleagues at the University of Pennsylvania describe...
Even though ApoE stands head and shoulders above other genetic risk factors for late-onset AD, few therapeutic strategies aimed at ApoE have made it to clinical trials...
Though it remains a prime pathological hallmark of Alzheimer disease, Aβ amyloid has yet to convincingly prove itself as the major toxic species driving AD...
The neuronal peptide α-synuclein is an important constituent of the Lewy bodies, pathological hallmarks of the Lewy body variant of Alzheimer's disease, as well as of Parkinson's and several other neurodegenerative diseases...