New online venues welcome data that tend to get the cold shoulder from traditional journals. They offer open peer review and the ability to link papers. Nice try or publishing revolution?
Multiple studies link the amount and processing of this cell surface protein to inflammation and neurodegeneration, although what it does remains unclear.
Scientists wonder if the sodium channel blocker might also slow disease progression.
Scientists correlate increased appetite and sugar cravings in frontotemporal dementia patients with localized atrophy in the brain.
Healthy neurons tell astrocytes how to act. In the case of ALS, astrocyte signals spell trouble.
Exercising the brain and body in middle age may not limit progression of Alzheimer’s pathology.
Proteolysis of other substrates, including Neuregulin, proceeds apace.
An Italian study links the supposedly protective ApoE2 gene to frontotemporal dementia in amyotrophic lateral sclerosis.
Researchers report the first successful use of this technology to detect soluble Aβ in the brains of Alzheimer’s mouse models.
Genetic deletion of white blood cells in an Alzheimer’s mouse model quadrupled plaque load, but restoring peripheral antibodies halved this increase.
Overly active interneurons fire up pyramidal neurons in mice with mutant TDP-43.
A new procedure turns circulating immune cells into neurons. It could simplify how scientists make patient-specific disease models.
Caging an HDAC inhibitor in a lipid chelator raised plasma and brain concentrations of the drug and doubled the lifespan of a mouse model of Niemann-Pick type C disease.
Some repeats seem to interfere with regulation of translation, causing dendrites to shrink.
Older people who regularly used proton pump inhibitors had a greater risk of mental decline.