DC: More MicroRNA Implicated in Dementia
Once thought to be a simple go-between, RNA is recently attracting much more attention as an important regulator of gene expression in its own right...
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DC: Primate, Mouse Studies Sustain Aβ Immunotherapy Hopes
Loaded with promise and disappointment, the roller-coaster tale of Alzheimer disease vaccine development has raised hopes and dampened some...
DC: Aβ Clearance—Roles for MBP, Transcription Factors?
Gumming up the brain years before a person may notice memory loss or other hints of Alzheimer disease, amyloid-β (Aβ) has fueled much of AD research...
DC: New Neprilysin Methods Reduce Brain Aβ
Neprilysin, one of a handful of proteases known to degrade amyloid-β (Aβ), might seem an attractive therapeutic for Alzheimer disease...
Big Ginkgo Prevention Trial Comes Up Negative
Older people who are buying and taking ginkgo biloba pills to ward off Alzheimer disease can save their money...
DC: Funding We Can Believe In? Perhaps, But Scientists Must Advocate
As representatives of the world’s 20 richest nations were meeting in Washington, DC, more than 31,000 scientists began arriving a few blocks away...
Research Brief: Calpain Inhibitor All Wrapped Up
Two groups report the crystal structure of the calcium-dependent protease calpain in complex with its endogenous inhibitor protein, calpastatin...
DIAN: International Network to Chart AD Preclinical Decade
The rarest kind of Alzheimer's disease, the form that is inherited from parent to child with a cruel 50 percent likelihood, has long been marked by its untapped opportunities. Affected families have made possible both the discovery of the first three
DIAN Part 3: Genetic and Data Protection for Volunteers
DIAN asks a lot of its study volunteers...
DIAN Part 2: The Science, Inner Workings of the Network
Scientifically, the Dominantly Inherited Alzheimer Network (DIAN) will test three hypotheses...
Imaging Studies Support Cognitive Reserve Theory
Just as cash in a rainy day fund can help people weather future economic downturns, extra years of school seem to have a protective effect in Alzheimer disease...
Jack of All Trades? Cdk5 Implicated in Neurotransmission, Neurogenesis
Cdk5’s repertoire is growing...
News Brief: Controversial ApoE Testing Ends for Now
A firm that offered ApoE genotyping to consumers online under the product name Alzheimer’s Mirror has shut down...
LOAD Genetics Study Is All in the Families
An analysis of genetic ties to late-onset Alzheimer disease (LOAD) is news not so much for its actual results, but instead for the potential it represents...
DIAN: Registry for eFAD to Chart Alzheimer’s Preclinical Decade
The rarest kind of Alzheimer disease (AD)—the autosomal-dominant form that runs in families—has long been marked by its untapped opportunities...
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