SLICK Science—Imaging Advances May Aid Brain Research
Peering through the dense thicket of axons and dendrites to figure out what individual neurons are up to in brain tissue is no mean feat...
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Peering through the dense thicket of axons and dendrites to figure out what individual neurons are up to in brain tissue is no mean feat...
The arrangement of linked brain regions into functional networks supports complex mental activity...
Hopes of harnessing the immune system to fight Alzheimer disease took another hit...
Boston: Neuroprotective Peptide Inches Forward in Clinic Strategic Research Institute’s Alzheimer Disease Conference
A trickle of data is starting to emerge from a Phase 2 clinical trial of a neuroprotective peptide...
At the Alzheimer’s Disease conference, Robert Vassar briefed the audience on his group’s latest work on the β-secretase BACE1...
Though ApoE4 is the most prevalent genetic risk factor for Alzheimer disease, its role in pathology has been tricky to pin down...
Keeping mitochondria trim and fit is good for your health, yet in Parkinson disease (PD) these organelles are all but healthy...
A third area of γ-secretase research that drew attention at the Keystone conference is the hotly debated question of how presenilin mutations cause familial Alzheimer disease...
Investigators described joint new research on how the lipid composition of the membrane influences the enzyme activity of γ-secretase...
Does a seven-year-old mouse model that mirrors schizophrenia traits bring good luck?...
Fiendishly complicated, γ-secretase inspires both awe and weariness...
The road to reliable preclinical AD biomarkers has proven long and difficult...
What is going on in older folks who seem to do fine with amyloid-peppered brains?...
Keystone: γ Slowly Relinquishes Its Secrets Keystone: Lipids Grease γ-Secretase Activity Keystone: Loss Versus Gain—Mutations a Drag on γ-Secretase Fiendishly complicated, γ-secretase has proved a formidable foe to the structurally minded scientist. But g