Like DLB, Like AD—Do Oligomers Stir Up the Trouble?
Current work on distinguishing Alzheimer disease from its cousin dementia with Lewy bodies has underscored one intriguing similarity between the two...
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Current work on distinguishing Alzheimer disease from its cousin dementia with Lewy bodies has underscored one intriguing similarity between the two...
Wnt signaling proteins act as forepersons for synapse assembly in developing animals—but they can be called out of retirement to do the same thing in adults...
Perhaps the biggest, and quintessential, representative of a spectrum neurodegenerative disease is dementia with Lewy bodies (DLB)...
Mutations in the Pink1 gene cause a recessive form of early-onset parkinsonism, and all the evidence points to mitochondria as the prime locus of the damage...
Thomas Gasser of the Hertie Institute in Tuebingen, Germany, presented data that illustrated two emerging concepts in neurodegenerative disease research...
For superoxide dismutase 1 (SOD1), the very features that allow the protein to do its job may make it prone to form abnormal aggregates...
Structural analyses offer insight into how a cancer drug stabilizes a tau pre-messenger RNA structure to curb production of a tau splice form that leads to dementia when made in excess...
Researchers have generated common marmosets that carry a transgene for enhanced green fluorescent protein (EGFP)...
Sometimes in science, a concept lingers unattended in the collective back of researchers’ minds for years...
Researchers coaxed huntingtin proteins to adopt distinct conformations in vitro under different temperatures, and showed that shape in large part determined toxicity...
ADNI: One-year Data Narrow Field of MRI, FDG-PET Approaches ADNI: Mission Creep From Alzheimer Disease to Healthy Senior? Preliminary and mostly unpublished, analysis of one-year data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) is in!
Cholesterol plays the villain in Alzheimer disease as an enabler of the production of toxic amyloid-β (Aβ) peptides, but it may have a second role as well...
The Alzheimer’s Disease Neuroimaging Initiative (ADNI) was originally conceived as an exploratory project to identify the best measures for tracking disease progression...
Alzheimer imaging aficionados gathered for a peek at the latest data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI)...
The oldest and the youngest people are often the most vulnerable to disease. The same might be true for cells...