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Some of the attention focused on amyloid-β may have to be diverted to yet another peptide product of amyloid precursor protein (APP). Daniel Lu, Edward Koo and colleagues report in the April issue of Nature Medicine that...
The DNA sequence of human chromosome 21 will be published electronically today in Nature (and in print on 18 May). This achievement, by an international consortium of 62 scientists reveals that chromosome 21...
According to a report in today's Science, a productive approach to combating the spongiform encephalopathies such as the transmissible "variant" Creutzfeldt-Jacob disease may be to attack cells in the spleen where...
The true identity of γ-secretase, the enzyme that frees amyloid-β from its membrane-bound precursor, is one of the holy grails in the search for the cause of Alzheimer's disease...
How are short-term memories converted to long-term memories? The process is certain to be complex, and a study in the 23 June issue of Science suggests thetranscription factor NPAS2 may play an important role...
Transplanted stem cells have provided compelling news stories in recent years, promising regeneration of damaged nervous systems, but another possibility—that the adult brain itself could provide the pluripotent cells...
One of the challenges to diagnosing Alzheimer's disease is the lack of a nonbehavioral clinical test. The definitive diagnosis can only be made when amyloid plaques and neurofibrillary tangles are seen at autopsy...
Finding a safe way to get therapeutic genes past the blood-brain barrier has led to some interesting approaches using the barrier's own transport systems to shuttle DNA across the blood capillary wall...
Results presented by three research groups this week all confirm that presenilin is, at the least, essential for γ-secretase to cleave amyloid precursor protein in the process that releases amyloid-β-...
Do individual neurons gradually waste away in inherited neurodegenerative diseases, or are they functioning more or less normally until one catastrophic event does them in? A study published in tomorrow's Nature suggests...
Epidemiological studies have hinted strongly that nonsteroidal anti-inflammatory drugs (NSAIDs) might delay the progression of Alzheimer's disease. In the August 1 issue of the Journal of Neuroscience...
A protein previously identified as a transporter of inorganic phosphate also transports glutamate into synaptic vesicles, according to a paper in today's Science...
A number of inherited neurodegenerative disorders (e.g., Huntingtons's disease and spinal and bulbar muscular atrophy) have been traced to the abnormal repetition of CAG sequences in the coding for particular proteins...
High-throughput screening for proteins is now possible, according to report in this month's Nature Biotechnology. Researchers in England have designed an array, similar to DNA microarrays, that can screen for more than 18,000 proteins at once...
The possibility of using stem cells from the brain to grow neural tissues has advanced a key step now that British scientists have coaxed certain nerve cells backwards in their development process to the stem cell stage...
