Paris: Diabetes, Insulin, and Alzheimer Disease
The mechanisms linking insulin to neurodegeneration were examined at the Fondation IPSEN 24th annual colloquium on Alzheimer’s Disease, held in Paris on 6 April 2009...
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The mechanisms linking insulin to neurodegeneration were examined at the Fondation IPSEN 24th annual colloquium on Alzheimer’s Disease, held in Paris on 6 April 2009...
Amyloid-β (Aβ) peptide oligomers have come under intense scrutiny as the prime suspects in the synapse loss and neurotoxicity associated with Alzheimer disease...
Researchers report that from a tiny injected seed, tau pathology eventually spreads to anatomically connected areas of the mouse brain...
To determine if a medicine works, scientists need reliable patient data, but the right numbers are not always easy to come by...
Amyotrophic lateral sclerosis, already a rare condition affecting one to three people in 100,000, nonetheless garners most of the attention in the field of motor neuron disease...
Two of the promises of genetic association studies are better animal models for research and development of therapeutics...
Calculating the risk of impending AD based on levels of CSF Aβ42 has been tricky because the peptide forms insoluble aggregates that muddle estimates of its production rate in the CNS...
Interest in hitting nicotinic acetylcholine receptors for AD treatment is smoldering just below the surface...
A recent population-based study supports the idea that in the oldest old, the relationship between plaques and tangles, and dementia, may be more legend than substance...
This penultimate article in this Alzforum series reports the call of a founding neurogeneticist to reorganize the genetics of Parkinson’s and related diseases...
This news story on the glucocerebrosidase (GBA) gene closes the Alzforum series on emerging concepts in the neurodegenerative disease spectrum...
The mystery of Huntington disease (HD) is how a toxic protein that is expressed in all the cells in the body kills only a select subset of neurons in the brain...
Scientists wrestling the complexities of α-synuclein fluid biochemistry might be forgiven for looking with some envy to a different protein of the neurodegenerative disease spectrum...
Aggregates of TAR DNA-binding Protein-43 are a bad sign in neurons, where they are found in some forms of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD)...
Presenilins deliver the final cut to unleash the Aβ peptides that form the amyloid plaques that gum up the brains of Alzheimer disease patients...