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Another Not-Quite-Parkinson's Model

A new mouse model of Parkinson's published in the current early online edition of PNAS develops a particularly severe motor disorder similar to Parkinson's disease but, as with a similar model reported last month, no degeneration of substantia nigra neurons...

Wingless Pathway Helps Tauopathy Take Off

The microtubule-associated protein tau is the major component of the intracellular neurofibrillary tangles (NFT) found in patients with various neurodegenerative disorders, including Alzheimer's and frontotemporal dementia. Scientists know that hyperphosphorylation of tau is at the root of its pathology, but...

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