No REST for Weary Neurons: Protective Factor Stems Cognitive Decline
Researchers identify a transcription factor that protects neurons during normal aging but goes AWOL in Alzheimer’s brains.
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Researchers identify a transcription factor that protects neurons during normal aging but goes AWOL in Alzheimer’s brains.
A single dose of a commonly prescribed antidepressant suppresses Aβ production in the human central nervous system.
A study suggests that genes involved in Aβ production and endocytosis mediate ApoE4’s role in Alzheimer’s disease.
New research suggests that α-synuclein comes in multiple strains, one of which seeds aggregation of tau.
Protein strains may underlie different tauopathies, according to researchers presented at this year's AAIC meeting in Boston.
Activating translation regulator eIF2alpha restores plasticity and memory in Alzheimer's models.
Researchers have detected elevated endogenous tau in the cerebrospinal fluid of Aβ mouse models.
By looking for structural DNA variations in Alzheimer’s families, researchers identified 18 new genes that may play a role in AD pathology.
Removing a key component of the innate immune system worsens amyloid deposition but improves memory in mice that model Alzheimer's pathology.
AD but no Amyloidβ? Researchers at AAIC 2013 theorized on the pathology underlying this form of dementia.
Advances in RNA sequencing are shedding light on gene regulation and helping scientists make sense of data from genome-wide association studies.
Conventional wisdom says that excess excitation promotes degeneration of motor neurons in ALS, but a new study suggests excitability could be a good thing.
A mouse study suggests it may be possible to co-opt the liver to boost expression of neurotrophins in the brain.
Two studies strengthen the link between shut-eye and Alzheimer’s disease, and a mouse analysis of how the brain drains waste offers insight into the connection.
Meet ADCS-PACC, C3: Composites that measure subtle changes in cognition appear reliable, clearing the way for their use in clinical trials of people with presymptomatic AD.